[PDF][PDF] A pan-cancer single-cell panorama of human natural killer cells

F Tang, J Li, L Qi, D Liu, Y Bo, S Qin, Y Miao, K Yu… - Cell, 2023 - cell.com
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor
progression. To depict their phenotypic and functional diversities in the tumor …

[HTML][HTML] Role of distinct natural killer cell subsets in anticancer response

H Stabile, C Fionda, A Gismondi, A Santoni - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells, the prototypic member of innate lymphoid cells, are important
effectors of anticancer immune response. These cells can survey and control tumor initiation …

[HTML][HTML] Cytokines orchestrating the natural killer-myeloid cell crosstalk in the tumor microenvironment: implications for natural killer cell-based cancer immunotherapy

S Gaggero, K Witt, M Carlsten, S Mitra - Frontiers in immunology, 2021 - frontiersin.org
Natural killer (NK) cells are endowed with germline-encoded receptors that enable them to
detect and kill malignant cells without prior priming. Over the years, overwhelming evidence …

The cancer–natural killer cell immunity cycle

ND Huntington, J Cursons, J Rautela - Nature Reviews Cancer, 2020 - nature.com
Immunotherapy with checkpoint blockade induces rapid and durable immune control of
cancer in some patients and has driven a monumental shift in cancer treatment. Neoantigen …

NK cells and cancer: you can teach innate cells new tricks

MG Morvan, LL Lanier - Nature Reviews Cancer, 2016 - nature.com
Natural killer (NK) cells are the prototype innate lymphoid cells endowed with potent cytolytic
function that provide host defence against microbial infection and tumours. Here, we review …

Roles of natural killer cells in immunity to cancer, and applications to immunotherapy

NK Wolf, DU Kissiov, DH Raulet - Nature Reviews Immunology, 2023 - nature.com
Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

[HTML][HTML] Therapeutic potential and challenges of natural killer cells in treatment of solid tumors

A Gras Navarro, AT Björklund, M Chekenya - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …

[HTML][HTML] Natural killer cells in cancer biology and therapy

SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …

[HTML][HTML] Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions

J Russick, PE Joubert, M Gillard-Bocquet… - … for Immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through
their cytotoxic effector functions and their capacity to interact with other immune cells to build …

[HTML][HTML] Natural killer cells: the linchpin for successful cancer immunotherapy

KA Shaver, TJ Croom-Perez, AJ Copik - Frontiers in immunology, 2021 - frontiersin.org
Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that
works by augmenting the body's own immune system. While various immune stimulation …