Moderate levels of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), fuel
tumor metastasis and invasion in a variety of cancer types. Conversely, excessive ROS …

Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is
the third most common cause of malignancy-associated mortality. Distant metastases to the …

Cancer cell survival is dependent on oxidative-stress defenses against reactive oxygen
species (ROS) that accumulate during tumorigenesis. Here, we show a non-canonical …

Macrophages (MΦs) and reactive oxygen species (ROS) are implicated in carcinogenesis.
The oxidative stress sensor, transient receptor potential ankyrin 1 (TRPA1), activated by …

The transient receptor potential ankyrin type 1 (TRPA1) channel belongs to the TRP
superfamily of ion channels. TRPA1 is a membrane protein with multiple functions able to …

To avoid reactive oxygen species (ROS)-induced cell death, cancer cells increase their
antioxidant defense system. In this issue of Cancer Cell, Takahashi et al. identify a novel …

Background: Transient receptor potential channels (TRP) are overexpressed in some
pancreatic adenocarcinoma (PDAC) patients and cell lines, settling them as putative …

Abstract Calcium (Ca 2+) is an essential signaling molecule in all cells. It is involved in
numerous fundamental functions, including cell life and death. Abnormal regulation of Ca 2+ …

Transient receptor potential ankyrin 1 (TRPA1) channels are expressed on the surface of
different cell types, including immune cells. However, TRPA1's role in the context of innate …

Oxidative stress arises from the inadequate production of reactive oxygen species (ROS)
which couldn't be neutralized by antioxidant defense. Cells maintain this balance of oxidants …