Although interactions between superoxide () and nitric oxide underlie many physiologic and
pathophysiologic processes, regulation of this crosstalk at the enzymatic level is poorly …

The recent discovery of a NOS1 gene product (ie a neuronal‐like isoform of nitric oxide
synthase or nNOS) in the mammalian left ventricular (LV) myocardium has provided a new …

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation.
To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS …

Emerging evidence shows that neuronal nitric oxide synthase (nNOS) plays several
diverging roles in modulating cardiac function. This review examines the nitric oxide (NO) …

Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …

Nitric oxide synthases are the major sources of nitric oxide, a critical signaling molecule
involved in a wide range of cellular and physiological processes. These enzymes comprise …

Myocardial constitutive No production depends on the activity of both endothelial and
neuronal NOS (eNOS and nNOS, respectively). Stimulation of myocardial β 3-adrenergic …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Significant advances in our understanding of the ability of nitric oxide synthases (NOS) to
modulate cardiac function have provided key insights into the role NOS play in the …

Endothelial nitric oxide synthase (eNOS) plays an important role in the control of myocardial
oxygen consumption (MVO2) by nitric oxide (NO). A NOS isoform is present in cardiac …