Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …

A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …

Enhancers establish spatial or temporal patterns of gene expression that are critical for
development, yet our understanding of how these DNA cis-regulatory elements function from …

Accurate control of gene expression in the right cell at the right moment is of fundamental
importance to animal development and homeostasis. At the heart of gene regulation lie the …

Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory …

Biological differences among metazoans and between cell types in a given organism arise
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …

Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …

Cell-type-and condition-specific profiles of gene expression require coordination between
protein-coding gene promoters and cis-regulatory sequences called enhancers. Enhancers …

Enhancer is a positive regulator for spatiotemporal development in eukaryotes. As a cluster,
super‐enhancer is closely related to cell identity‐and fate‐determined processes. Both of …

It is now well accepted that cell-type specific gene regulation is under the purview of
enhancers. Great strides have been made recently to characterize and identify enhancers …