While cancer remains a significant global health problem, advances in cancer biology, deep
understanding of its underlaying mechanism and identification of specific molecular targets …

Over the last years, drug repurposing has become a hot topic within the pharmaceutical
industry and academia. In fact, several economic and time-related benefits are on the basis …

Drug repositioning, also known as drug repurposing, reprofiling, or rediscovery, is
considered to be one of the most promising strategies to accelerate the development of new …

Introduction: In the past, clinical studies had demonstrated that aspirin and NSAIDs reduce
the risk of colorectal cancer. After the discovery of selective prostaglandin-endoperoxide …

Abstract A cyclooxygenase-2 (COX-2) inhibitor celecoxib has been previously reported to
have cytotoxic activities towards gastric, prostate, ovarian, colon and breast cancer cell lines …

Introduction: The COX enzymes play a central role in the biosynthetic pathway of important
biological mediators called prostanoids. Differences in regulation of gene expression …

Background and Objectives: It is generally accepted that inflammatory cells found in the
tumor microenvironment are involved in the neoplastic process, promoting cell proliferation …

Celecoxib is a nonsteroidal anti‐inflammatory drug (NSAID) designed to be a selective
cyclooxygenase‐2 (COX‐2) inhibitor. It was approved by the US Food and Drug …

Celecoxib is a paradigmatic selective inhibitor of cyclooxygenase-2 (COX-2). This anti-
inflammatory drug has potent anti-tumor activity in a wide variety of human epithelial tumor …

Cyclooxygenase-2 (COX-2) is an important enzyme involved in prostaglandins biosynthesis
from arachidonic acid. COX-2 is frequently overexpressed in human cancers and plays a …