Pharmacokinetics of Quercetin‐Loaded Methoxy Poly (ethylene glycol)‐b‐poly (L‐lactic acid) Micelle after Oral Administration in Rats

L Lv, C Liu, Z Li, F Song, G Li… - BioMed Research …, 2017 - Wiley Online Library
The purpose of this study was to evaluate the potential of micelle to change the
pharmacokinetics of quercetin (QUT), with a primary goal of enhancing its oral …

Enhancing oral bioavailability of quercetin using novel soluplus polymeric micelles

L Dian, E Yu, X Chen, X Wen, Z Zhang, L Qin… - Nanoscale research …, 2014 - Springer
To improve its poor aqueous solubility and stability, the potential chemotherapeutic drug
quercetin was encapsulated in soluplus polymeric micelles by a modified film dispersion …

Preparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery

Z Lu, C Bu, W Hu, H Zhang, M Liu… - Bioscience …, 2018 - academic.oup.com
Quercetin (QT) is a plant polyphenol with various pharmacological properties. However, the
low water solubility limits its therapeutic efficacy. In the present study, QT-loaded sodium …

Formulation and in vitro evaluation of quercetin loaded polymeric micelles composed of pluronic P123 and Da-tocopheryl polyethylene glycol succinate

L Zhao, Y Shi, S Zou, M Sun, L Li… - Journal of biomedical …, 2011 - ingentaconnect.com
The objective of this study was to develop a polymeric delivery system to improve the
solubility and biological activity of Quercetin (QT). QT loaded mixed micelles, composed of …

Development of quercetin nanoformulation and in vivo evaluation using streptozotocin induced diabetic rat model

D Chitkara, SK Nikalaje, A Mittal, M Chand… - Drug delivery and …, 2012 - Springer
Quercetin-loaded poly (lactic-co-glycolic acid)(PLGA) nanoparticles (Qu-NP) were prepared
by emulsion–diffusion–evaporation method and characterized as 179.9±11.2 nm in size with …

Polymer type and molecular weight dictate the encapsulation efficiency and release of Quercetin from polymeric micelles

S Sunoqrot, A Alsadi, O Tarawneh… - Colloid and Polymer …, 2017 - Springer
Flavonoids such as quercetin (QCT) represent a diverse class of natural compounds with
unique therapeutic potential in cancer and inflammatory diseases. However, their clinical …

Development and characterization of self-assembling lecithin-based mixed polymeric micelles containing quercetin in cancer treatment and an in vivo …

LC Chen, YC Chen, CY Su, CS Hong… - International Journal …, 2016 - Taylor & Francis
Quercetin (Que) is known to have biological benefits including an anticancer effect, but low
water solubility limits its clinical application. The aim of this study was to develop a lecithin …

Lecithin-Stabilized Polymeric Micelles (LsbPMs) for Delivering Quercetin: Pharmacokinetic Studies and Therapeutic Effects of Quercetin Alone and in Combination …

CE Chang, CM Hsieh, SC Huang, CY Su, MT Sheu… - Scientific reports, 2018 - nature.com
In this study, lecithin-stabilized polymeric micelles (L sb PMs) were prepared to load
quercetin (QUE) in order to improve its bioavailability and increase its antitumor activity. Its …

Rp-HPLC determination of quercetin in a novel D-α-tocopherol polyethylene glycol 1000 succinate based SNEDDS formulation: Pharmacokinetics in Rat Plasma

OAA Ahmed, HM El-Bassossy, HM El-Sayed… - Molecules, 2021 - mdpi.com
Despite its proven efficacy in diverse metabolic disorders, quercetin (QU) for clinical use is
still limited because of its low bioavailability. D-α-Tocopherol polyethylene glycol 1000 …

Comparative Serum and Brain Pharmacokinetics of Quercetin after Oral and Nasal Administration to Rats as Lyophilized Complexes with β-Cyclodextrin Derivatives …

K Manta, P Papakyriakopoulou, A Nikolidaki, E Balafas… - Pharmaceutics, 2023 - mdpi.com
Quercetin (Que) is one of the most studied flavonoids with strong antioxidant properties
ascribed to its ability to bind free radicals and inactivate them. However, the low solubility of …