Background. Brain injury is the leading cause of death following cardiac arrest (CA) and
cardiopulmonary resuscitation (CPR). Ac2‐26 and endothelial nitric oxide synthase (eNOS) …

Background Cardiopulmonary bypass (CPB) results in brain injury, which is primarily
caused by inflammation. Ac2-26 protects against ischemic or hemorrhage brain injury. The …

Background Neuroinflammation and apoptosis are involved in the pathogenesis of
ischaemic stroke. Alisol A 24-acetate (24A) exerts a strong inhibitory effect on inflammation …

C5a receptor 1 (C5aR1) can induce a strong inflammatory response to an injury. Targeting
C5aR1 has emerged as a novel anti-inflammatory therapeutic method. However, the role of …

Background Cerebral ischemia–reperfusion injury (CIRI) is the leading cause of poor
neurological prognosis after cardiopulmonary resuscitation (CPR). We previously reported …

Background Death among resuscitated patients is mainly caused by brain injury after
cardiac arrest/cardiopulmonary resuscitation (CA/CPR). The angiotensin converting enzyme …

Injury to the blood‐brain barrier (BBB) plays a vital role in sepsis‐associated
encephalopathy (SAE), which is one of the most common complications of sepsis. GYY4137 …

Cardiac arrest (CA) causes ischemia-reperfusion injury in the whole body among victims.
Especially in the brain, inflammation and neuronal cell death can lead to irreversible …

Ischemia/reperfusion caused by cardiac arrest (CA) disturbs endoplasmic reticulum (ER)
homeostasis and redox balance in neurons. AA147, originally developed as a …

Objective: Global cerebral ischemia-induced neuroinflammation causes neurofunctional
impairment following cardiac arrest. Previous studies have demonstrated that the activation …