The presence of the blood–brain barrier (BBB) restricts the movement of soluble mediators
and leukocytes from the periphery to the central nervous system (CNS). Leukocyte entry into …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system associated
with demyelination and axonal loss eventually leading to neurodegeneration. MS exhibits …

In most regions of the central nervous system (CNS), the composition of the neuronal
microenvironment is maintained by virtue of particular blood–brain-barrier (BBB) …

The blood-brain barrier (BBB) is a complex organization of cerebral endothelial cells (C EC),
pericytes and their basal lamina, which are surrounded and supported by astrocytes and …

Blood–brain barrier (BBB) breakdown and immune cell infiltration into the CNS are early
hallmarks of multiple sclerosis (MS). The mechanisms leading to BBB dysfunction are …

The blood-brain barrier (BBB) provides both anatomical and physiological protection for the
central nervous system (CNS), strictly regulating the entry of many substances and blood …

Each year about 650,000 Europeans die from stroke and a similar number lives with the
sequelae of multiple sclerosis (MS). Stroke and MS differ in their etiology. Although cause …

The blood-brain barrier (BBB) cellular constituents and their molecular interactions critically
regulate immune activation within the central nervous system (CNS) such that it is protected …

Blood-brain barrier (BBB) disruption has long been recognised as an important early feature
of multiple sclerosis (MS) pathology. Traditionally, this has been seen as a by-product of the …

The delicate microenvironment of the central nervous system (CNS) is protected by the
blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB). These barriers …