Abstract Purpose Angiotensin II (Ang II)-induced vascular contraction is mediated by Ca 2+-
dependent mechanisms and Ca 2+ sensitization mechanisms. The phosphorylation of …

BACKGROUND: Angiotensin II (Ang II)-induced vascular contraction is mediated both by a
Ca 2+-mediated signaling pathway and a Ca 2+ sensitization mechanism. We recently …

Background Whether volatile anesthetics attenuate angiotensin II-mediated vascular tone
has not been determined. The current study was designed to investigate the effects of …

IMPLICATIONS: The present study demonstrates that sevoflurane can dose-dependently
inhibit both angiotensin II (Ang II)-induced contraction and p44/42 MAPK phosphorylation of …

Background Vascular smooth muscle tone is regulated by changes in intracellular free Ca2+
concentration ([Ca2+] i) and myofilament Ca2+ sensitivity. These cellular mechanisms could …

Abstract Purpose Angiotensin II (Ang II)-induced vasoconstriction is mediated by changes in
intracellular free Ca 2+ concentration ([Ca 2+] i) and myofilament Ca 2+ sensitivity. Protein …

The present study investigated the direct action of propofol on guinea pig basilar arterial
rings and the possible underlying mechanisms. Arterial rings, with and without endothelium …

Background: Propofol induces dose‐dependent vasodilation and hypotension in the clinical
situation, and protein kinase C (PKC)‐mediated Ca2+ sensitization plays an important role …

BACKGROUND: Vascular contraction is regulated by myosin light chain (MLC)
phosphorylation. Inhibition of MLC phosphatase (MLCP) increases MLC phosphorylation for …

Background Angiotensin II (AngII) is a potent vasoconstrictor involved in the short-term
control of arterial blood pressure. Isoflurane was reported to decrease vascular tone through …