Controversy remains about the causative mediators in the bronchoconstrictive response to
exercise in asthma. This study examined whether mast cell activation is a feature of exercise …

In order to assess the role of mast cell-derived mediators in the pathogenesis of••
rciseinduced asthma (EIA), we completed pre-and postexercise bronchoalveolar lavage …

Exercise-induced asthma (EIA) may affect up to 90% of patients with asthma. Hyperpnea
associated with exercise leads to increased airway water and heat loss, which contributes to …

Purpose The purpose of this study was to clarify the role of mast cell mediators in the airway
response to exercise in athletes and to investigate the effect of SCG. Methods Eleven …

To determine whether mediators of immediate hypersensitivity played a role in the
pathogenesis of exercise-induced asthma, we measured the concentration of histamine and …

Background: Mannitol‐induced bronchoconstriction in subjects with exercise‐induced
asthma is associated with increased urinary excretion of 9α, 11β‐PGF2, a metabolite of …

Rationale: Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with
unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ regarding …

We investigated the effects of terfenadine, a histamine H1-receptor antagonist, and
flurbiprofen, a cyclooxygenase inhibitor, on exercise-induced bronchoconstriction to assess …

The aim of this study was to investigate if mannitol inhalation, as a model of exercise-
induced bronchoconstriction (EIB), causes mast cell activation and release of mediators of …

Dehydration of the airways results in release of mediators. The likely source of these
mediators is the mast cell. Epithelial injury occurs in exercise-induced bronchoconstriction …