[HTML][HTML] Systemic 7-methylxanthine in retarding axial eye growth and myopia progression: a 36-month pilot study

K Trier, S Munk Ribel-Madsen, D Cui… - Journal of ocular biology …, 2008 - Springer
Abstract The adenosine antagonist 7-methylxanthine (7-mx) works against myopia in animal
models. In a clinical trial, 68 myopic children (mean age 11.3 years) received either placebo …

[HTML][HTML] The adenosine receptor antagonist, 7-methylxanthine, alters emmetropizing responses in infant macaques

LF Hung, B Arumugam, L Ostrin, N Patel… - … & visual science, 2018 - jov.arvojournals.org
Purpose: Previous studies suggest that the adenosine receptor antagonist, 7-methylxanthine
(7-MX), retards myopia progression. Our aim was to determine whether 7-MX alters the …

Oral administration of caffeine metabolite 7-methylxanthine is associated with slowed myopia progression in Danish children

K Trier, D Cui, S Ribel-Madsen… - British Journal of …, 2023 - bjo.bmj.com
Purpose Myopia is associated with an increased risk of permanent vision loss. The caffeine
metabolite 7-methylxanthine (7-MX), licensed in Denmark since 2009 as a treatment to …

[HTML][HTML] Myopia, its prevalence, current therapeutic strategy and recent developments: A Review

H Singh, H Singh, U Latief, GK Tung… - Indian journal of …, 2022 - journals.lww.com
Myopia is a widespread and complex refractive error in which a person's ability to see
distant objects clearly is impaired. Its prevalence rate is increasing worldwide, and as per …

The role of atropine eye drops in myopia control

A Grzybowski, A Armesto… - Current …, 2015 - ingentaconnect.com
High myopia is a major cause of uncorrectable visual impairment. It imposes major
challenges and costs for refractive correction, and for the treatment of associated …

[HTML][HTML] Effects of 7-methylxanthine on form-deprivation myopia in pigmented rabbits

HH Nie, LJ Huo, X Yang, ZY Gao, JW Zeng… - International journal …, 2012 - ncbi.nlm.nih.gov
AIM To determine the effect of 7-methylxanthine (7-MX) on the posterior sclera of form-
deprivation myopia (FDM) in pigmented rabbits. METHODS Sixteen pigmented rabbits were …

Effects of 7‐methylxanthine on the sclera in form deprivation myopia in guinea pigs

D Cui, K Trier, J Zeng, K Wu, M Yu, J Hu… - Acta …, 2011 - Wiley Online Library
Purpose: The aim of this study was to determine the effect of the adenosine receptor
antagonist 7‐methylxanthine (7‐MX) on form deprivation myopia in 3‐week‐old guinea pigs …

[HTML][HTML] Safety and efficacy of 0.02% and 0.01% atropine on controlling myopia progression: a 2-year clinical trial

C Cui, X Li, Y Lyu, L Wei, B Zhao, S Yu, J Rong… - Scientific Reports, 2021 - nature.com
Four hundred myopic children randomly received atropine 0.02%(n= 138) or 0.01%(n= 142)
in both eyes once-nightly or only wore single-vision spectacles (control group)(n= 120) for 2 …

Atropine in ameliorating the progression of myopia in children with mild to moderate myopia: a meta-analysis of controlled clinical trials

Y Song, H Wang, B Wang, H Qi, Z Rong… - Journal of ocular …, 2011 - liebertpub.com
Objectives: Myopia is the most common ocular disorder associated with increasing risk for
chorioretinal degeneration, retinal detachment, and other vision-threatening abnormalities …

[HTML][HTML] Clinical efficacy of 0.01% atropine in retarding the progression of myopia in children

Q Zhao, Q Hao - International ophthalmology, 2021 - Springer
Purpose To investigate the clinical efficacy of 0.01% atropine in slowing the progression of
myopia in children and to evaluate the influence of 0.01% atropine on secretion of basal tear …