Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis

C Florean, S Song, M Dicato, M Diederich - Free Radical Biology and …, 2019 - Elsevier
Redox changes and generation of reactive oxygen species (ROS) are part of normal cell
metabolism. While low ROS levels are implicated in cellular signaling pathways necessary …

The interplay of oncogenic signaling, oxidative stress and ferroptosis in cancer

W Zeng, X Long, PS Liu, X Xie - International Journal of Cancer, 2023 - Wiley Online Library
Oncogene‐induced hyper‐proliferation in cancer cells is accompanied by the onset of
different stresses, including DNA‐replication stress, metabolic stress and oxidative stress …

Reactive oxygen species and cancer paradox: to promote or to suppress?

S Galadari, A Rahman, S Pallichankandy… - Free Radical Biology …, 2017 - Elsevier
Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

The molecular mechanisms of regulating oxidative stress‐induced Ferroptosis and therapeutic strategy in tumors

J Zhu, Y Xiong, Y Zhang, J Wen, N Cai… - Oxidative Medicine …, 2020 - Wiley Online Library
Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis,
necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron‐dependent …

Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases

Y Lv, M Wu, Z Wang, J Wang - Cell Biology and Toxicology, 2023 - Springer
Ferroptosis is a regulated cell death mainly manifested by iron-dependent lipid peroxide
accumulation. The leading cause of ferroptosis is the imbalance of intracellular oxidative …

The role of ferroptosis in cancer development and treatment response

B Lu, XB Chen, MD Ying, QJ He, J Cao… - Frontiers in …, 2018 - frontiersin.org
Ferroptosis is a process driven by accumulated iron-dependent lipid ROS that leads to cell
death, which is a distinct regulated cell death comparing to other cell death. The lethal …

[HTML][HTML] Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers

M Jiang, M Qiao, C Zhao, J Deng, X Li… - … lung cancer research, 2020 - ncbi.nlm.nih.gov
Ferroptosis is a novel form of non-apoptotic regulated cell death (RCD), with distinct
characteristics and functions in physical conditions and multiple diseases such as cancers …

Reactive oxygen species (ROS) regulates different types of cell death by acting as a rheostat

GE Villalpando-Rodriguez… - Oxidative Medicine and …, 2021 - Wiley Online Library
Reactive oxygen species (ROS) are essential for cellular signaling and response to stress.
The level of ROS and the type of ROS determine the ability of cells to undergo cell death …

From oxytosis to ferroptosis: 10 years of research on oxidative cell death

D Tang, R Kang - Antioxidants & Redox Signaling, 2023 - liebertpub.com
Over the past decade, extensive research has been dedicated to understanding oxidative
cell death, specifically the transition from oxytosis to ferroptosis. Oxytosis was initially …

Metabolic regulation of ferroptosis in cancer

MJ Kim, GJ Yun, SE Kim - Biology, 2021 - mdpi.com
Simple Summary Ferroptosis is a recently defined nonapoptotic form of cell death that is
associated with various human diseases, including cancer. As ferroptosis is caused by an …