Plasma fibrin clot proteomics in healthy subjects: Relation to clot permeability and lysis time

M Ząbczyk, A Stachowicz, J Natorska, R Olszanecki… - Journal of …, 2019 - Elsevier
Background Little is known about fibrin clot composition in relation to its structure and
lysability. We investigated plasma clots protein composition and its associations with clot …

Optimization of quantitative proteomic analysis of clots generated from plasma of patients with venous thromboembolism

A Stachowicz, J Siudut, M Suski, R Olszanecki… - Clinical proteomics, 2017 - Springer
Background It is well known that fibrin network binds a large variety of proteins, including
inhibitors and activators of fibrinolysis, which may affect clot properties, such as stability and …

Plasma fibrin clot proteomics in patients with acute pulmonary embolism: association with clot properties

AH Bryk, J Natorska, M Ząbczyk, K Zettl… - Journal of …, 2020 - Elsevier
It has been reported that 476 proteins can be detected in plasma fibrin clots from patients
with venous thromboembolism. Plasma fibrin clots proteomic composition in relation to their …

Shotgun analysis of plasma fibrin clot-bound proteins in patients with acute myocardial infarction

M Suski, J Siudut, M Ząbczyk, R Korbut… - Thrombosis research, 2015 - Elsevier
Introduction The presence and amount of the proteins within a plasma clot may influence
clot properties, like susceptibility to fibrinolysis, however, the clot proteome has not yet been …

Determinants of plasma fibrin clot lysis measured using three different assays in healthy subjects

J Siudut, T Iwaniec, K Plens, M Pieters, A Undas - Thrombosis Research, 2021 - Elsevier
Introduction Several methods for measuring fibrinolytic capacity in plasma have been
developed yielding frequently inconsistent results. We investigated which factors determine …

[HTML][HTML] Clot structure and fibrinolysis in thrombosis and hemostasis

Z Bagoly, RAS Ariëns, DC Rijken… - BioMed Research …, 2017 - ncbi.nlm.nih.gov
“Inimicum quamvis humilem metuendum est”(“An enemy, however small, is to be feared”).
Today, thrombotic disorders are major contributors to the global burden of disease [1]. The …

How to assess fibrinogen levels and fibrin clot properties in clinical practice?

A Undas - Seminars in Thrombosis and Hemostasis, 2016 - thieme-connect.com
Fibrin formed from fibrinogen is the main component of thrombi. Clot structure is
characterized by fiber thickness and pore size, which differs within a given clot and between …

Fibrin clot properties and their modulation in thrombotic disorders

A Undas - Thrombosis and haemostasis, 2014 - thieme-connect.com
Accumulating evidence indicates that accelerated formation of fibrin clots composed of
compact, highly-branched networks with thin fibres which are relatively resistant to plasmin …

Plasma Fibrin Clot Properties as Determinants of Bleeding Time in Human Subjects: Association with Histidine‐Rich Glycoprotein

K Szułdrzyński, M Jankowski, DP Potaczek… - Disease …, 2020 - Wiley Online Library
Aims. Fibrin formation and histidine‐rich glycoprotein (HRG) are involved in primary
hemostasis and wound healing. Little is known regarding the relationship of clot …

An international study on the feasibility of a standardized combined plasma clot turbidity and lysis assay: communication from the SSC of the ISTH

M Pieters, H Philippou, A Undas, Z de Lange… - Journal of Thrombosis …, 2018 - jthjournal.org
Abnormal fibrin clot structure, in particular increased fibrin fiber density and stiffness and
resistance to fibrinolysis, are reported to be linked to cardiovascular disease (CVD) and a …