Apoptosis of articular chondrocytes is associated with the pathogenesis of osteoarthritis
(OA). Recently, we demonstrated that hypoxia-inducible factor (HIF)-2α, encoded by Epas1 …

The hallmark of OA is cartilage destruction, several factors such as catabolic enzymes and
chondrocyte death include apoptosis and/or autophagy are considered for the …

Objective Hypoxia‐inducible factor 2α (HIF‐2α)(encoded by Epas1) causes osteoarthritic
(OA) cartilage destruction by regulating the expression of catabolic factor genes. We …

The goal of our investigation was to explore the mechanism by which hypoxia regulates
growth plate chondrocyte survival. At low O2 tension, chondrocytes were refractory to a …

Objective To investigate the relationship between hypoxia inducible factor-1α (HIF-1α) and
the autophagic response in osteoarthritic chondrocytes (OA), under inflammatory insult as …

Chondrocyte apoptosis is closely related to the development and progression of
osteoarthritis (OA); however, the underlying mechanisms remain enigmatic. Previous studies …

Transcription factor hypoxia-inducible factor (HIF)-1 protein accumulates and activates the
transcription of genes that are of fundamental importance for oxygen homeostasis–including …

Osteoarthritis (OA) is a common disabling disease which has a high incidence rate in the
elderly. Studies have found that many factors are involved in the pathogenesis of OA …

Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and
catabolic factors. Here, we show that hypoxia-inducible factor-2α (HIF-2α, encoded by …

Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …