Antibiotic tolerance is the ability of a susceptible population to survive high doses of cidal
drugs and has been shown to compromise therapeutic outcomes in bacterial infections. In …

Metabolic sensing tips the balance of drug tolerance in fungal meningitis | Nature Microbiology
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We have investigated the potential of the GTP synthesis pathways as chemotherapeutic
targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal …

Invasive fungal infections cause 1.6 million deaths annually, primarily in
immunocompromised individuals. Mortality rates are as high as 90% due to limited …

Amphotericin B (AmB) is used to treat cryptococcal meningoencephalitis. However, the
mortality rate remains high. Higher doses of AmB in deoxycholate buffer (AmBd) are toxic to …

Cryptococcus neoformans is an encapsulated yeast responsible for approximately a quarter
of a million deaths worldwide annually despite therapy, and upwards of 11% of HIV/AIDS …

Cryptococcal meningoencephalitis is an urgent global health problem. Induction regimens
using 14 days of amphotericin B deoxycholate (dAmB) are considered the standard of care …

Although the pathogenesis of cerebral cryptococcosis is poorly understood, local immune
cells, such as microglia and astrocytes, likely play a critical role in containing infection …

Chronic meningoencephalitis is caused by Cryptococcus neoformans and is treated in many
parts of the world with fluconazole (FLC) monotherapy, which is associated with treatment …

With the inclusion in this issue of the Journal of the study by Day et al. on the treatment of
cryptococcal meningitis, 1 the Journal has provided the medical community with a trilogy of …