The general model presented here for the formation of chromatin domains, LADs and TADs,
is primarily based on the 3-D structures of the corresponding DNA sequences, the GC-poor …

Recent investigations have shown that isochores are characterized by a 3-D structure which
is primarily responsible for the topology of chromatin domains. More precisely, an analysis of …

The ring-like cohesin complex mediates sister chromatid cohesion by encircling pairs of
sister chromatids. Cohesin also extrudes loops along chromatids. Whether the two activities …

Chromatin loops stack up | Nature Reviews Genetics Skip to main content Thank you for visiting
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Mammalian genomes are organized into compartments, topologically-associating domains
(TADs) and loops to facilitate gene regulation and other chromosomal functions …

Mammalian genomes are spatially organized into compartments, topologically associating
domains (TADs), and loops to facilitate gene regulation and other chromosomal functions …

The ring-like cohesin complex mediates sister-chromatid cohesion by encircling pairs of
sister chromatids. Cohesin also extrudes loops along chromatids. Whether the two activities …

The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function
together to shape chromatin architecture in mammalian cells, but the molecular details of …

The interphase genome is mainly shaped by cohesin-mediated loop extrusion and cohesin-
independent compartmentalization. Extrusion is a dynamic process of cohesin loading, loop …

The spatial organization of the eukaryotic genome plays an important role in regulating
transcriptional activity. In the nucleus, chromatin forms loops that assemble into fundamental …