Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors.
Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK …

The Janus kinases (JAKs) are a pivotal family of protein tyrosine kinases (PTKs) that play
prominent roles in numerous cytokine signaling pathways, with aberrant JAK activity …

Cytokines signal through cell surface receptor dimers to initiate activation of intracellular
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …

Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal
transduction pathways that govern cellular survival, proliferation, differentiation and …

The Janus kinases (JAKs) and their downstream effectors, signal transducer and activator of
transcription proteins (STATs), form a critical immune cell signaling circuit, which is of …

Background: Cytokines mediate a variety of effector cell functions, including cellular
proliferation, differentiation, and modulation of the immune response. Many cytokines …

Cytokines are critically important for the growth and development of a variety of cells. Janus
kinases (JAKs) associate with cytokine receptors and are essential for transmitting …

Cytokines play crucial roles in the growth and differentiation of hematopoietic cells. They
bind to specific cell membrane receptors that usually do not possess intrinsic protein …

Janus kinases comprise carboxyterminal kinase, pseudokinase, SH2-like, and N-terminal
FERM domains. We identified three patient-derived mutations in the FERM domain of Jak3 …

The Janus kinases are considered to be cytoplasmic kinases that constitutively associate
with the cytoplasmic region of cytokine receptors, and the Janus kinases (Jaks) are crucial …