Effects of intranasal treatment with slow (GYY4137) and rapid (NaHS) donors of hydrogen sulfide in lipopolysaccharide-induced airway inflammation in mice

Y Kaya-Yasar, Y Karaman, TE Bozkurt… - Pulmonary …, 2017 - Elsevier
We have investigated the effects of slow (GYY4137) and rapid (NaHS) hydrogen sulfide (H 2
S) releasing donors in lipopolysaccharide (LPS)-induced airway inflammation in mice. LPS …

Hydrogen sulfide donors prevent lipopolysaccharide‐induced airway hyperreactivity in an in vitro model of chronic inflammation in mice

Y Karaman, Y Kaya‐Yasar, TE Bozkurt… - Basic & Clinical …, 2021 - Wiley Online Library
We aimed to investigate and compare the effects of rapid (NaHS) and slow (GYY4137 and
AP39) hydrogen sulfide (H2S) releasing donors on LPS‐induced tracheal hyperreactivity …

The effect of mitochondria-targeted slow hydrogen sulfide releasing donor AP39-treatment on airway inflammation

Y Karaman, Y Kaya-Yasar, CC Eylem, SC Onder… - European Journal of …, 2023 - Elsevier
Mitochondrial dysfunction has been shown to contribute to the pathophysiology of airway
diseases. Therefore, mitochondria are targeted in the development of new therapeutic …

Hydrogen sulfide is an antiviral and antiinflammatory endogenous gasotransmitter in the airways. Role in respiratory syncytial virus infection

T Ivanciuc, E Sbrana, M Ansar, N Bazhanov… - American journal of …, 2016 - atsjournals.org
Hydrogen sulfide (H2S) is an endogenous gaseous transmitter whose role in the
pathophysiology of several lung diseases has been increasingly appreciated. Our recent …

Inhaled hydrogen sulfide protects against lipopolysaccharide-induced acute lung injury in mice

S Faller, KK Zimmermann, KM Strosing… - Medical gas …, 2012 - Springer
Background Local pulmonary and systemic infections can lead to acute lung injury (ALI).
The resulting lung damage can evoke lung failure and multiple organ dysfunction …

The role of hydrogen sulphide in lung diseases

CHK Wu - Bioscience Horizons, 2013 - academic.oup.com
Hydrogen sulphide (H2S) is a recently discovered gasotransmitter. It is endogenously
synthesized by cystathionine β synthetase, cystathionine γ lyase, cysteine aminotransferase …

Hydrogen sulfide inhibits apoptosis and protects the bronchial epithelium in an allergic inflammation mice model

JA Mendes, MC Ribeiro, GJMV Reis Filho… - International …, 2019 - Elsevier
Studies suggest that hydrogen sulfide (H 2 S) plays a relevant and beneficial role in the
pathophysiology of pulmonary allergic diseases, such as asthma. These diseases may be …

[HTML][HTML] Hydrogen sulfide inhibits oxidative stress in lungs from allergic mice in vivo

LR Benetti, D Campos, SA Gurgueira… - European journal of …, 2013 - Elsevier
Recent studies show that endogenous hydrogen sulfide (H2S) plays an anti-inflammatory
role in the pathogenesis of airway inflammation. This study investigated whether exogenous …

A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo

CW Huang, W Feng, MT Peh, K Peh, BW Dymock… - Pharmacological …, 2016 - Elsevier
Exogenous hydrogen sulfide (H 2 S) is known to exert anti-inflammatory effects both in
macrophages and in animal models. In this study, we first showed that NaHS caused a …

Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma

YH Chen, R Wu, B Geng, YF Qi, PP Wang, WZ Yao… - Cytokine, 2009 - Elsevier
Endogenous hydrogen sulfide (H2S) is hypothesized to have an important role in systemic
inflammation. We investigated if endogenous H2S may be a crucial mediator in airway …