The complement membrane attack complex (MAC) is classically known as a cytolytic effector
of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or …

The membrane attack complex (MAC) is the pore-forming toxin of the complement system, a
relatively early evolutionary acquisition that confers upon complement the capacity to …

The final common pathway of all routes of complement activation involves the non-
enzymatic assembly of a complex comprising newly formed C5b with the plasma proteins …

The soluble membrane attack complex (sMAC, aka, sC5b-9 or TCC) is generated on
activation of complement and contains the complement proteins C5b, C6, C7, C8, C9 …

Complement activation, triggered through classic, alternative, or lectin pathways of
activation, leads to activation of a final common reaction sequence, the membrane attack …

Activation of the complement cascade and subsequent assembly of the membrane attack
complex (MAC) occur in a number of pathophysiological settings. When formed on the …

The membrane attack complex (MAC) is an important innate immune effector of the
complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite …

Our understanding of the biology of the complement system has undergone a drastic
metamorphosis since its original discovery. This system, which was traditionally primarily …

The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

Progress at the beginning of the 21st century transformed the perception of complement
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …