It has been proposed that many human cancers are generated by intrinsic mechanisms that
produce “Bad Luck” mutations by the proliferation of organ-specific adult stem cells. There …

Cancer is driven by genomic mutations in 'cancer driver'genes, which have essential roles in
tumor development. These mutations may be caused by exposure to mutagens in the …

that Krasactivation increased the competitiveness of crypt stem cells but not to an entirely
deterministic level: 80% of cell replacement events that involved Kras-mutant cells led to the …

Somatic cell mutations arising in vivo in reporter genes and in cancer-associated genes may
now be measured in humans. Background mutation levels and mutational responses …

Some cancers can be cured by chemotherapy or radiotherapy, presumably because they
are derived from those cell types that not only can die easily but also have already been …

Cancer is a genetic disease due to the accumulation of numerous mutations rendering the
tumour cell insensitive to control by the local cellular environment and by the whole …

Mutation accumulation in stem cells has been associated with cancer risk. However, the
presence of numerous mutant clones in healthy tissues has raised the question of what …

We explore the phenomenon of somatic mutations, including those in cancer driver genes,
that are present in healthy, normal-appearing tissues and their potential implications for …

It is impossible to predict exactly who will develop a cancer and who will not. We know that
several “risk factors” may increase the chance of getting cancer and that risk increases with …

Publisher Summary The chapter examines what is known (and what is unknown) and what
might be deduced indirectly concerning the frequency of somatic mutations in terms of …