NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma
Abstract The NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is
an immunological sensor that detects a wide range of microbial-and host-derived signals …
an immunological sensor that detects a wide range of microbial-and host-derived signals …
An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
Increasing complexity of NLRP3 inflammasome regulation
J Moretti, JM Blander - Journal of Leucocyte Biology, 2021 - academic.oup.com
Inflammasomes are multiprotein complexes that assemble upon detection of danger signals
to activate the inflammatory enzyme caspase-1, trigger secretion of the highly …
to activate the inflammatory enzyme caspase-1, trigger secretion of the highly …
Mechanism of NLRP3 inflammasome activation
FS Sutterwala, S Haasken… - Annals of the New York …, 2014 - Wiley Online Library
Inflammasomes continue to generate interest in an increasing number of disciplines owing
to their unique ability to integrate a myriad of signals from pathogen‐and damage …
to their unique ability to integrate a myriad of signals from pathogen‐and damage …
Human NLRP1: From the shadows to center stage
S Bauernfried, V Hornung - Journal of Experimental Medicine, 2021 - rupress.org
In response to infection or cell damage, inflammasomes form intracellular multimeric protein
complexes that play an essential role in host defense. Activation results in the maturation …
complexes that play an essential role in host defense. Activation results in the maturation …
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
J Tschopp, K Schroder - Nature reviews immunology, 2010 - nature.com
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein
complex that activates caspase 1, leading to the processing and secretion of the pro …
complex that activates caspase 1, leading to the processing and secretion of the pro …
Posttranslational regulation of the NLR family pyrin domain-containing 3 inflammasome
DW Shim, KH Lee - Frontiers in immunology, 2018 - frontiersin.org
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-
protein complex that can be activated by a variety of pathogen-associated molecular …
protein complex that can be activated by a variety of pathogen-associated molecular …
Sensing damage by the NLRP3 inflammasome
JC Leemans, SL Cassel… - Immunological reviews, 2011 - Wiley Online Library
The NLRP3 inflammasome is activated in response to a variety of signals that are indicative
of damage to the host including tissue damage, metabolic stress, and infection. Upon …
of damage to the host including tissue damage, metabolic stress, and infection. Upon …
Negative regulation of NLRP3 inflammasome signaling
S Chen, B Sun - Protein & cell, 2013 - Springer
Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation
and interleukin-1β (IL-1β) maturation as well as pyroptosis. Though a number of …
and interleukin-1β (IL-1β) maturation as well as pyroptosis. Though a number of …