Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

M Di Martile, S Garzoli, M Sabatino, E Valentini… - Cell death …, 2021 - nature.com
Essential oils (EOs) have been recently emerging for their promising biological activities in
preventing tumorigenesis or progression of different tumor histotypes, including melanoma …

[HTML][HTML] Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol

SJ Greay, DJ Ireland, HT Kissick, A Levy… - Cancer Chemotherapy …, 2010 - Springer
Purpose To examine the in vitro anticancer activity of Melaleuca alternifolia (tea tree) oil
(TTO), and its major active terpene component, terpinen-4-ol, against two aggressive murine …

Essential oils and their main chemical components: The past 20 years of preclinical studies in melanoma

M Di Martile, S Garzoli, R Ragno, D Del Bufalo - Cancers, 2020 - mdpi.com
Simple Summary In the last years, targeted therapy and immunotherapy modified the
landscape for metastatic melanoma treatment. These therapeutic approaches led to an …

A narrative review of the antitumor activity of monoterpenes from essential oils: An update

TQ Machado, ACC Da Fonseca… - BioMed research …, 2022 - Wiley Online Library
Monoterpenes are a group of natural products that have been widely studied due to their
therapeutic potential against various pathologies. These compounds are abundant in the …

Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells

MR Loizzo, R Tundis, F Menichini, AM Saab… - Cell …, 2008 - Wiley Online Library
Objectives: The purpose of this study was to evaluate cytotoxic activity of Platycladus
orientalis, Prangos asperula and Cupressus sempervirens ssp. pyramidalis essential oils …

[HTML][HTML] Resveratrol analogue, trans-4, 4′-dihydroxystilbene (DHS), inhibits melanoma tumor growth and suppresses its metastatic colonization in lungs

B Saha, GB Pai, M Subramanian, P Gupta… - Biomedicine & …, 2018 - Elsevier
The prevalence of melanoma and the lack of effective therapy for metastatic melanoma
warrant extensive and systematic evaluations of small molecules in cellular and pre-clinical …

[HTML][HTML] Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells

A Calcabrini, A Stringaro, L Toccacieli… - Journal of Investigative …, 2004 - Elsevier
The search for innovative therapeutic approaches based on the use of new substances is
gaining more interest in clinical oncology. In this in vitro study the potential anti-tumoral …

Anticancer effect of terpenes: focus on malignant melanoma

P Wróblewska-Łuczka, J Cabaj, J Bargieł… - Pharmacological …, 2023 - Springer
Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for a
significant proportion of cancer-related deaths worldwide. Although conventional cancer …

Plant-derived terpenoids: a promising tool in the fight against melanoma

P Kłos, D Chlubek - Cancers, 2022 - mdpi.com
Simple Summary Despite the numerous therapies, melanoma remains the deadliest of all
skin cancers; however, plant-derived terpenoids are defense molecules that have proven …

Exploring the potent anticancer activity of essential oils and their bioactive compounds: Mechanisms and prospects for future cancer therapy

F Mohamed Abdoul-Latif, A Ainane… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the leading causes of death worldwide, affecting millions of people each
year. Fortunately, the last decades have been marked by considerable advances in the field …