Background Silent cerebral infarcts are the most common neurologic injury in children with
sickle cell anemia and are associated with the recurrence of an infarct (stroke or silent …

Children with sickle cell disease (SCD) and strokes receive blood transfusion therapy for
secondary stroke prevention; despite this, approximately 20% experience second overt …

Background: Silent cerebral infarct (SCI) is the most common cause of serious neurological
disease in sickle cell anemia (SCA), affecting approximately 22% of children. The goal of …

Although long-term transfusion therapy is at least 90% effective in preventing recurrent
strokes after an initial cerebrovascular accident in patients with sickle cell disease, it is …

Silent cerebral infarct (SCI) is the most common form of neurologic disease in children with
sickle cell anemia (SCA). SCI is defined as abnormal magnetic resonance imaging (MRI) of …

Objective: To test the hypothesis that children with sickle cell disease (SCD) who have an
initial stroke temporally unrelated to another medical event are at higher risk for recurrent …

We hypothesized that the silent cerebral infarcts (SCI), which affect up to 40% of children
with sickle cell disease (SCD), could occur in the setting of acute anemic events. In a …

Children with sickle cell anemia (HbSS) are at high risk for neurologically overt cerebral
infarcts associated with stroke and neurologically silent cerebral infarcts correlated with …

Objective: To determine whether children with homozygous sickle cell anemia (SCD) who
have silent infarcts on magnetic resonance imaging (MRI) of the brain are at increased risk …

Background. Silent infarcts have been reported in 17% of young patients with sickle cell
disease and are associated with impaired performance on standardized psychometric tests …