Regulatory T Cells for Control of Autoimmunity

R Kawakami, S Sakaguchi - Basic Immunology and Its Clinical Application, 2024 - Springer
Regulatory T (Treg) cells, which specifically express the master transcription factor FoxP3,
are indispensable for the maintenance of immunological self-tolerance and homeostasis …

Regulatory T–cells: origin and function

IS Freidlin - Medical Immunology (Russia), 2014 - mimmun.ru
Over the past decade a population of so–called “regulatory T cells”(Treg cells) has been
linked to the prevention of autoimmunity. In this review we discuss the molecular …

Regulatory T cells and human disease

S Sakaguchi, N Mikami, JB Wing… - Annual review of …, 2020 - annualreviews.org
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

Regulatory T cells: history and perspective

S Sakaguchi - Regulatory T cells: methods and protocols, 2011 - Springer
Despite the skepticism that once prevailed among immunologists, it is now widely accepted
that the normal immune system harbors a T-cell population, called regulatory T cells (Treg …

Induced Foxp3+ regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?

Q Lan, H Fan, V Quesniaux, B Ryffel… - Journal of molecular …, 2012 - academic.oup.com
Foxp3+ T regulatory cells (Tregs) consisting of natural and induced Treg subsets play a
crucial role in the maintenance of immune homeostasis against self-antigen. The actions …

Regulatory T cells as therapeutic targets and mediators

A Sharma, D Rudra - International Reviews of Immunology, 2019 - Taylor & Francis
With the advent of the concept of dominant tolerance and the subsequent discovery of CD4+
regulatory T cells expressing the transcription factor FOXP3 (Tregs), almost all productive as …

New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression

N Mikami, R Kawakami, S Sakaguchi - Current opinion in immunology, 2020 - Elsevier
Naturally occurring FoxP3+ CD4+ regulatory T (Treg) cells indispensable for the
maintenance of immunological self-tolerance and homeostasis are instrumental in treating …

The progress and prospect of regulatory T cells in autoimmune diseases

X Zhang, N Olsen, SG Zheng - Journal of Autoimmunity, 2020 - Elsevier
Regulatory T cells (Treg) are an important immune cell population, playing a crucial role in
regulating immune tolerance and preventing autoimmune diseases. These cells consist of …

The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases

A Mohr, M Atif, R Balderas, G Gorochov… - Clinical & …, 2019 - academic.oup.com
CD4+ regulatory T cells (Treg) expressing the forkhead box protein 3 (FOXP3) transcription
factor (Tregs) are instrumental for the prevention of autoimmune diseases. There is …

Regulatory T cells

S Sakaguchi - Springer seminars in immunopathology, 2006 - Springer
There is accumulating evidence that regulatory T cells (Tregs), once called suppressor T
cells, are present in the normal immune system as an essential cellular component for …