Chronic pain is highly comorbid with affective disorders, including major depressive
disorder. A core feature of major depressive disorder is a loss of interest in previously …

Physical pain (induced by tissue damage) and psychological pain (induced by surprising
incentive loss) share a set of common neural substrates, but little is known about their …

Pain disorders and psychiatric illness are strongly comorbid, particularly in the context of
Major Depressive Disorder (MDD). While these disorders account for a significant amount of …

The notion that reward inhibits pain is a well-supported observation in both humans and
animals, allowing suppression of pain reflexes to acquired rewarding stimuli. However, a …

The therapeutic goals of patients with chronic pain are not only to relieve pain but also to
improve the quality of life. Chronic pain negatively affects various aspects of daily life, such …

Introduction Pain catastrophizing, a measure of an individual's negative emotional and
cognitive appraisals of pain, has been included as a key treatment target in many …

Clinically, pain is a complex phenomenon consisting of both sensory and affective
aberrations that can persist indefinitely. Pre-clinically, several animal paradigms have been …

Chronic pain may alter both affect-and value-related behaviors, which represents a
potentially treatable aspect of chronic pain experience. Current understanding of how …

In addition to sensory disturbances, neuropathic pain is associated with an ongoing and
persistent negative affective state. This condition may be reflected as altered sensitivity to …

Both short-and long-term pain influence reward processing. Albeit the literature is still
scarce, a picture is emerging in which pain increases the motivational drive to obtain reward …