Impact of donor age on the osteogenic supportive capacity of mesenchymal stromal cell-derived extracellular matrix
MS Carvalho, L Alves, I Bogalho… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSC) have been proposed as an emerging cell-based
therapeutic option for regenerative medicine applications as these cells can promote tissue …
therapeutic option for regenerative medicine applications as these cells can promote tissue …
Cultured cell‐derived extracellular matrices to enhance the osteogenic differentiation and angiogenic properties of human mesenchymal stem/stromal cells
Cell‐derived extracellular matrix (ECM) consists of a complex assembly of fibrillary proteins,
matrix macromolecules, and associated growth factors that mimic the composition and …
matrix macromolecules, and associated growth factors that mimic the composition and …
Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of …
D Hanetseder, T Levstek, AH Teuschl-Woller… - … in Bioengineering and …, 2023 - frontiersin.org
Regeneration of bone defects is often limited due to compromised bone tissue physiology.
Previous studies suggest that engineered extracellular matrices enhance the regenerative …
Previous studies suggest that engineered extracellular matrices enhance the regenerative …
Systemic mesenchymal stromal cell transplantation prevents functional bone loss in a mouse model of age-related osteoporosis
J Kiernan, S Hu, MD Grynpas, JE Davies… - Stem cells …, 2016 - academic.oup.com
Age-related osteoporosis is driven by defects in the tissue-resident mesenchymal stromal
cells (MSCs), a heterogeneous population of musculoskeletal progenitors that includes …
cells (MSCs), a heterogeneous population of musculoskeletal progenitors that includes …
Aging of bone marrow mesenchymal stromal/stem cells: Implications on autologous regenerative medicine
N Charif, YY Li, L Targa, L Zhang, JS Ye… - Bio-Medical …, 2017 - content.iospress.com
With their proliferation, differentiation into specific cell types, and secretion properties,
mesenchymal stromal/stem cells (MSC) are very interesting tools to be used in regenerative …
mesenchymal stromal/stem cells (MSC) are very interesting tools to be used in regenerative …
Osteogenic differentiation of human mesenchymal stromal cells and fibroblasts differs depending on tissue origin and replicative senescence
V Grotheer, N Skrynecki, L Oezel, J Windolf… - Scientific reports, 2021 - nature.com
The need for an autologous cell source for bone tissue engineering and medical
applications has led researchers to explore multipotent mesenchymal stromal cells (MSC) …
applications has led researchers to explore multipotent mesenchymal stromal cells (MSC) …
Age-related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development
Aging at the cellular level is a complex process resulting from accumulation of various
damages leading to functional impairment and a reduced quality of life at the level of the …
damages leading to functional impairment and a reduced quality of life at the level of the …
Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells
OS Beane, VC Fonseca, LL Cooper, G Koren… - PloS one, 2014 - journals.plos.org
Mesenchymal stem/stromal cells (MSCs) are promising cell sources for regenerative
therapies due to their multipotency and ready availability, but their application can be …
therapies due to their multipotency and ready availability, but their application can be …
Comparative proteomic profiling of human osteoblast‐derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation …
M Baroncelli, BC van der Eerden… - Journal of Cellular …, 2018 - Wiley Online Library
The extracellular matrix (ECM) is a dynamic component of tissue architecture that physically
supports cells and actively influences their behavior. In the context of bone regeneration, cell …
supports cells and actively influences their behavior. In the context of bone regeneration, cell …
Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells
G Siegel, T Kluba, U Hermanutz-Klein, K Bieback… - BMC medicine, 2013 - Springer
Abstract Background Mesenchymal stromal cells (MSCs) are attractive for cell-based
therapies ranging from regenerative medicine and tissue engineering to immunomodulation …
therapies ranging from regenerative medicine and tissue engineering to immunomodulation …