Prior tumor cell studies have shown that the drugs sorafenib (Nexavar) and regorafenib
(Stivarga) reduce expression of the chaperone GRP78. Sorafenib/regorafenib and the multi …

The chaperone GRP78/Dna K is conserved throughout evolution down to prokaryotes. The
GRP78 inhibitor OSU‐03012 (AR‐12) interacted with sildenafil (Viagra) or tadalafil (Cialis) …

Therapeutic targeting of the tumor vasculature that destroys preexisting blood vessels of the
tumor and antiangiogenesis therapy capitalize on the requirement of tumor cells on an intact …

The protein chaperone GRP78 is a master regulator of endoplasmic reticulum (ER) functions
and is frequently over-expressed at the surface of cancer cells where it contributes to chemo …

We examined the interaction between OSU‐03012 (also called AR‐12) with
phosphodiesterase 5 (PDE5) inhibitors to determine the role of the chaperone glucose …

K-Ras is a well-studied oncogene, and its mutation is frequently found in epithelial cancers
like pancreas, lung, and colorectal cancers. Cancer cells harboring K-Ras mutations are …

Background GRP78, the 78-kDa glucose-regulated protein, occupies a significant position in
endoplasmic reticulum stress. Emerging evidences have shown that GRP78 induces …

Treatment of several types of cancer such as lung, breast, prostate, and pancreas has
shown notable progresses in the past decades. However, after an initial response, tumors …

Antiangiogenic effects of the proteasome inhibitor bortezomib were analyzed on tumor
xenografts in vivo. Bortezomib strongly inhibited angiogenesis and vascularization in the …

Glucose‐regulated protein of 78 kD (GRP78) is a chaperone protein mainly located in the
endoplasmic reticulum (ER). This protein is normally present at low levels in adult cells but …