Cytokine signaling has been connected to regulation of metabolism and energy balance.
Numerous cytokine gene expression changes are stimulated by accumulation of bile acids …

Bile acids are powerful detergents produced by the liver to aid in the absorption of dietary
lipids. We recently reported a novel role for Foxa2 in bile acid metabolism. The winged helix …

FoxO transcription factors are important targets of insulin action. To better understand the
role of FoxO proteins in the liver, we created transgenic mice expressing constitutively active …

Forkhead transcription factor Foxa2 activates genes involved in hepatic lipid metabolism
and is regulated by insulin. Activation of Foxa2 in the liver leads to increased oxidation and …

The forkhead box proteins A1 and A2 (Foxa1 and Foxa2) are transcription factors with
critical roles in establishing the developmental competence of the foregut endoderm and in …

Adipose tissue should not be considered a simple fat sink but a specialized system that
promptly and dynamically responds to variations of nutrients, to fulfil its major role in whole …

Abstract Forkhead transcription factor 3 (FOXA3) has been shown to regulate metabolism
and development. Hepatic FOXA3 is reduced in obesity and fatty liver disease. However, the …

FOXA2 has been known to play important roles in liver functions in rodents. However, its role
in human hepatocytes is not fully understood. Recently, we generated FOXA2 mutant …

The forkhead transcription factor Foxo1 regulates expression of genes involved in stress
resistance and metabolism. To assess the contribution of Foxo1 to metabolic dysregulation …

Triglyceride accumulation in nonalcoholic fatty liver (NAFL) results from unbalanced lipid
metabolism which, in the liver, is controlled by several transcription factors. The Foxa …