The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of
immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg …

T regulatory cells (Tregs) control immune homeostasis by preventing inappropriate
responses to self and nonharmful foreign antigens. Tregs use multiple mechanisms to …

Regulatory T cells (Treg) comprise multiple subsets and are important in controlling
immunity and inflammation. However, the induction and mode of action of the various …

Chemokines and chemokine receptors establish a complex network modulating immune cell
migration and localization. These molecules were also suggested to mediate the …

Immune tolerance and activation depend on precise control over the number and function of
immunosuppressive Foxp3+ regulatory T (T reg) cells, and the importance of IL-2 in …

A single G protein–coupled receptor (GPCR) can activate multiple signaling cascades
based on the binding of different ligands. The biological relevance of this feature in immune …

CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) are potent suppressors of the adaptive
immune system, but their effects on innate immune cells are less well known. Here we …

Regulatory T (Treg) cells have emerged as a central control point in the modulation of
various immune responses, including autoimmune responses and immunity to transplants …

Abstract Foxp3+ CD25+ CD4+ Treg play a fundamental role in the maintenance of self
tolerance and the control of inflammatory reactions. Previous data demonstrated a division …

CCR7-mediated migration of naive T cells into the secondary lymphoid organs is a
prerequisite for their encounter with mature dendritic cells, the productive presentation of …