Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to
glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but …

Glucagon‐like peptide‐1 (GLP‐1) is an incretin hormone that underlies the augmented
insulin release from the pancreas in response to glucose in the gut lumen more than to …

In view of the importance of molecular sensing in the function of the gastrointestinal (GI)
tract, we assessed whether signal transduction proteins that mediate taste signaling are …

Many of the receptors and downstream signaling elements involved in taste detection and
transduction are also expressed in enteroendocrine cells where they underlie the …

BACKGROUND & AIMS: Enteroendocrine cells are thought to directly sense nutrients via α-
gustducin coupled taste receptors (originally identified in the oral epithelium) to modulate …

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
are released during meals from endocrine cells located in the gut mucosa and stimulate …

Epithelial cells lining the inner surface of the intestinal epithelium are in direct contact with a
lumenal environment that varies dramatically with diet. It has long been suggested that the …

The composition of the intestinal luminal content varies considerably with diet. It is important
therefore that the intestinal epithelium senses and responds to these significant changes …

Nutrient-evoked gastrointestinal reflexes are likely initiated by specialized epithelial cells
located in the small intestine that detect luminal stimuli and release mediators that activate …

Dietary sugars are transported from the intestinal lumen into absorptive enterocytes by the
sodium-dependent glucose transporter isoform 1 (SGLT1). Regulation of this protein is …