Reperfusion of ischemic tissue induces an acute inflammatory response that can result in
necrosis and irreversible cell injury to both local vascular endothelium and parenchyma. To …

Reperfusion of ischemic tissue is associated with tissue injury greater than that resulting
from ischemia alone. C activation has been hypothesized to mediate the so-called …

The relative inflammatory roles of neutrophils, selectins, and terminal complement
components are investigated in this study of skeletal muscle reperfusion injury. Mice …

INTRODUCTION: The injury caused by reperfusion of ischemic skeletal muscle is mediated
by the membrane attack complex of complement (C). This C activation results from local …

After skeletal muscle ischemia, tissue damage is augmented during reperfusion. White
blood cells (WBCs) and complement proteins may participate in the reperfusion injury. The …

Ischemia-reperfusion (I/R) injury provides a substantial limitation to further improvements in
the development of therapeutic strategies for ischemia-related diseases. Studies in animal …

Myocardial concentrations of C1q, a subunit of the first component of complement, were
measured 5-120 minutes after ligation of a coronary artery in dogs injected with 125I-labeled …

Reperfusion injury of ischemic tissue represents an acute inflammatory response that can
cause significant morbidity and mortality. The mechanism of injury is not fully elucidated, but …

We sought to determine whether the third component of complement (C3) is localized in
ischemic baboon myocardium after coronary artery ligation. Furthermore, we assessed the …

Activation of the classical complement pathway represents an effector mechanism of
intestinal ischemia/reperfusion injury. Mice deficient in complement receptors 1 and 2 fail to …