We previously demonstrated that human keratinocytes produce and secrete endothelins
(ET), which can be strong mitogens for human melanocytes. Ultraviolet B (UVB) exposure …

The paracrine linkage of endothelins (ET) between keratinocytes and melanocytes
suggested that ETs are intrinsic mediators for human melanocytes in UVB‐induced …

The human epidermal-melanin unit exists as a complex interplay of cell-cell interactions.
Melanocytes synthesize melanin and transfer it to the surrounding keratinocytes, which, in …

We recently demonstrated that human melanocyte proliferation and differentiation could be
stimulated by endothelin (ET) derivatives via a receptor-mediated signal transduction …

Melanocytes synthesize melanin and transfer it to keratinocytes via dendritic processes.
Keratinocytes are known to produce constitutively several factors, including endothelin-1 (ET …

Abstract Endothelin (ET)-1, alpha-melanocyte stimulating hormone (alpha-melanotropin;
alpha-MSH), and basic fibroblast growth factor (bFGF) are keratinocyte-derived factors that …

Recently we demonstrated that endothelins secreted from human keratinocytes act as
intrinsic mitogens and melanogens for human melanocytes in UVB-induced melanosis. We …

Little is known about the mechanism (s) underlying hyperpigmentation in lentigo senilis. We
have previously reported that keratinocyte-derived endothelins are intrinsic paracrine …

We demonstrate here that human melanocytes could be regulated by endothelin (ET)
derivatives, potent vasoconstrictive peptides synthesized by endothelial cells, to stimulate …

Endothelin (ET-1) has been shown to crucially contribute to UV-induced skin responses
such as tanning. To test whether ET-1 is also involved in early cutaneous reactions to UV …