Multi-physics interactions drive VEGFR2 relocation on endothelial cells
Abstract Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) is a pro-angiogenic
receptor, expressed on endothelial cells (ECs). Although biochemical pathways that follow …
receptor, expressed on endothelial cells (ECs). Although biochemical pathways that follow …
Modeling and simulation of VEGF receptors recruitment in angiogenesis
A Salvadori, V Damioli, C Ravelli… - … Problems in Engineering, 2018 - Wiley Online Library
Angiogenesis, the process of new blood vessel formation from preexisting ones, plays a
pivotal role in tumor growth. Vascular endothelial growth factor receptor‐2 (VEGFR2) is the …
pivotal role in tumor growth. Vascular endothelial growth factor receptor‐2 (VEGFR2) is the …
[HTML][HTML] Heterogeneity in VEGF receptor-2 mobility and organization on the endothelial cell surface leads to diverse models of activation by VEGF
The dynamic nanoscale organization of cell surface receptors plays an important role in
signaling. We determine this organization and its relation to activation of VEGF receptor-2 …
signaling. We determine this organization and its relation to activation of VEGF receptor-2 …
A model of integrin and vegf receptors recruitment on endothelial cells
Angiogenesis is a multistep process in which endothelial cells (ECs) are affected by several
extracellular stimuli, including growth factors, extracellular matrix (ECM), and parenchymal …
extracellular stimuli, including growth factors, extracellular matrix (ECM), and parenchymal …
Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells
S Sarabipour, K Kinghorn, KM Quigley… - PLoS computational …, 2024 - journals.plos.org
The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
Role of nanomechanics in canonical and noncanonical pro-angiogenic ligand/VEGF receptor-2 activation
Vascular endothelial growth factor receptor-2 (VEGFR2) is an endothelial cell receptor that
plays a pivotal role in physiologic and pathologic angiogenesis and is a therapeutic target …
plays a pivotal role in physiologic and pathologic angiogenesis and is a therapeutic target …
Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis
JM Boucher, RP Clark, DC Chong, KM Citrin… - Nature …, 2017 - nature.com
Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is
essential for development, wound healing and disease. Membrane-localized vascular …
essential for development, wound healing and disease. Membrane-localized vascular …
Endothelial cell orientation and polarity are controlled by shear stress and VEGF through distinct signaling pathways
AC Vion, T Perovic, C Petit, I Hollfinger… - Frontiers in …, 2021 - frontiersin.org
Vascular networks form, remodel and mature under the influence of multiple signals of
mechanical or chemical nature. How endothelial cells read and interpret these signals, and …
mechanical or chemical nature. How endothelial cells read and interpret these signals, and …
VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis
CS Abhinand, R Raju, SJ Soumya, PS Arya… - Journal of cell …, 2016 - Springer
Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions
associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2 …
associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2 …
Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells
The vascular endothelial growth factor receptors (VEGFRs) can shape the neovascular
phenotype of vascular endothelial cells when translocated to the nucleus, however the …
phenotype of vascular endothelial cells when translocated to the nucleus, however the …