Understanding of embryonic development has led to the clinical application of Assisted
Reproductive technologies (ART), with the resulting birth of millions of children. Recent …

Dynamic metabolism is exhibited by early mammalian embryos to support changing cell
fates during development. It is widely acknowledged that metabolic pathways not only satisfy …

Early mammalian embryogenesis is currently the focus of intense interest because of the
potential of inner cell mass-derived embryonic stem cell lines in new therapeutic strategies …

Unicellular organisms are exquisitely sensitive to nutrient availability in the environment and
have evolved elaborate mechanisms to sense the levels and types of nutrients, altering …

The advent of metabolomics technology and its application to small samples has allowed us
to non-invasively monitor the metabolic activity of embryos in a complex culture …

The preimplantation embryo must satisfy dynamic changes in energy demand during
development to the blastocyst stage. Energy is provided through regulated metabolic …

During early mammalian embryogenesis, changes in cell growth and proliferation depend
on strict genetic and metabolic instructions. However, our understanding of metabolic …

Mammalian life begins with the fusion of an oocyte and a sperm, and these two terminally
differentiated germ cells are converted into a totipotent zygote. Zygote then undergoes a …

Emerging and seminal studies have shown that cell metabolism influences gene expression
by modifying the epigenome, which can regulate stem cell pluripotency, differentiation, and …

Along with standard morphological indicators of preimplantation embryo development,
information gained from novel “Omics” platforms is providing more detailed functional …