Recent advances in cell-free synthetic biology have given rise to gene circuit-based sensors
with the potential to provide decentralized and low-cost molecular diagnostics. However, it …

Cell-free transcription–translation systems have great potential for biosensing, yet the range
of detectable chemicals is limited. Here we provide a workflow to expand the range of …

Whole-cell biosensors have several advantages for the detection of biological substances
and have proven to be useful analytical tools. However, several hurdles have limited whole …

Synthetic gene networks have wide-ranging uses in reprogramming and rewiring
organisms. To date, there has not been a way to harness the vast potential of these networks …

It is recognized that biocomputing can provide intelligent solutions to complex biosensing
projects. However, it remains challenging to transform biomolecular logic gates into …

Accurate and accessible nucleic acid diagnostics is critical to reducing the spread of COVID-
19 and resuming socioeconomic activities. Here, we present an integrated platform for the …

Cell-free biosensors are powerful platforms for monitoring human and environmental health.
Here, we expand their capabilities by interfacing them with toehold-mediated strand …

An increasing interest in building novel biological devices with designed cellular
functionalities has triggered the search of innovative tools for biocomputation. Utilizing the …

Abstract Characterization and standardization of inducible transcriptional regulators has
transformed how scientists approach biology by allowing precise and tunable control of …

Portable, low-cost and quantitative detection of a broad range of targets at home and in the
field has the potential to revolutionize medical diagnostics and environmental monitoring …