A unique bacterial secretion machinery with multiple secretion centers

L Song, JD Perpich, C Wu, T Doan… - Proceedings of the …, 2022 - National Acad Sciences
The Porphyromonas gingivalis type IX secretion system (T9SS) promotes periodontal
disease by secreting gingipains and other virulence factors. By in situ cryoelectron …

PorM, a core component of bacterial type IX secretion system, forms a dimer with a unique kinked-rod shape

K Sato, K Okada, K Nakayama, K Imada - Biochemical and Biophysical …, 2020 - Elsevier
Porphyromonas gingivalis, which is a major pathogen of the periodontal disease, secrets
virulence factors such as gingipain proteases via the type IX secretion system (T9SS). T9SS …

Characterization of the Porphyromonas gingivalis type IX secretion trans-envelope PorKLMNP core complex

MS Vincent, MJ Canestrari, P Leone… - Journal of Biological …, 2017 - ASBMB
The transport of proteins at the cell surface of Bacteroidetes depends on a secretory
apparatus known as type IX secretion system (T9SS). This machine is responsible for the …

Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System

DG Gorasia, PD Veith, EG Hanssen, MD Glew… - PLoS …, 2016 - journals.plos.org
The type IX secretion system (T9SS) has been recently discovered and is specific to
Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis …

Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system

D Mizgalska, T Goulas… - Proceedings of the …, 2021 - National Acad Sciences
Porphyromonas gingivalis is a keystone pathogen of the human dysbiotic oral microbiome
that causes severe periodontitis. It employs a type-IX secretion system (T9SS) to shuttle …

The type IX secretion system and its role in bacterial function and pathogenesis

PD Veith, MD Glew, DG Gorasia… - Journal of Dental …, 2022 - journals.sagepub.com
Porphyromonas, Tannerella, and Prevotella species found in severe periodontitis use the
Type IX Secretion System (T9SS) to load their outer membrane surface with an array of …

Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas …

AM Lasica, T Goulas, D Mizgalska, X Zhou… - Scientific Reports, 2016 - nature.com
Porphyromonas gingivalis is a member of the human oral microbiome abundant in dysbiosis
and implicated in the pathogenesis of periodontal (gum) disease. It employs a newly …

The type IX secretion system: advances in structure, function and organisation

DG Gorasia, PD Veith, EC Reynolds - Microorganisms, 2020 - mdpi.com
The type IX secretion system (T9SS) is specific to the Bacteroidetes phylum. Porphyromonas
gingivalis, a keystone pathogen for periodontitis, utilises the T9SS to transport many proteins …

Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space

P Leone, J Roche, MS Vincent, QH Tran… - Nature …, 2018 - nature.com
Type IX secretion system (T9SS), exclusively present in the Bacteroidetes phylum, has been
studied mainly in Flavobacterium johnsoniae and Porphyromonas gingivalis. Among the 18 …

Imaging the assembly, structure and activity of type III secretion systems

J Enninga, I Rosenshine - Cellular microbiology, 2009 - Wiley Online Library
The type III secretion system (T3SS) is a sophisticated molecular machinery of Gram‐
negative bacteria used to 'inject'(translocate) bacterial proteins (effectors) into eukaryotic …