Cholesterol remains a vital molecule required for life; however, increasing evidence exists
implicating cholesterol in cancer development and progression. Numerous studies …

Cholesterol is crucial for cell survival and growth, and dysregulation of cholesterol
homeostasis has been linked to the development of cancer. The tumor microenvironment …

Cholesterol is a lipid molecule that plays an essential role in a number of biological
processes, both physiological and pathological. It is an essential structural constituent of cell …

Increasing evidence suggested that cholesterol is an important integrant of cell membranes,
that plays a key role in tumor progression, immune dysregulation, and pathological changes …

Cholesterol is an essential structural component of membranes that contributes to
membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the …

Previous studies demonstrated that three-dimensional (3D) multicellular tumor spheroids
(MCTS) could more closely mimic solid tumors than two-dimensional (2D) cancer cells in …

Aberrant lipid accumulation and marked changes in cellular lipid profiles are related to
breast cancer metabolism and disease progression. In vitro, these phenomena are primarily …

Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Bioactive lipid molecules have been proposed to play important roles linking
obesity/metabolic syndrome and cancers. Studies reveal that aberrant lipid metabolic …

Cholesterol is an essential component of cell membranes and helps to maintain their
structure and function. Abnormal cholesterol metabolism has been linked to the …