Integrated SERS-vertical flow biosensor enabling multiplexed quantitative profiling of serological exosomal proteins in patients for accurate breast cancer subtyping

X Su, X Liu, Y Xie, M Chen, C Zheng, H Zhong, M Li - ACS nano, 2023 - ACS Publications
Protein profiles of exosomes (EXOs) in clinical samples of cancer patients have become a
promising diagnostic and therapeutic biomarker. However, simultaneous quantitative …

Absolute quantification of serum exosomes in patients with an sers-lateral flow strip biosensor for noninvasive clinical cancer diagnosis

X Su, Y Xie, X Liu, M Chen, C Zheng… - ACS Applied Materials …, 2023 - ACS Publications
Exosomes (exos) widely existing in body fluids show great potential for noninvasive cancer
diagnosis. Quantitative analysis of exos is traditionally performed by targeting specific …

Label-free nanosensing platform for breast cancer exosome profiling

N Ferreira, A Marques, H Aguas, H Bandarenka… - ACS …, 2019 - ACS Publications
Breast cancer accounts for 11.6% of all cancer cases in both genders. Even though several
diagnostic techniques have been developed, the mostly used are invasive, complex, time …

Artificial intelligent label-free SERS profiling of serum exosomes for breast cancer diagnosis and postoperative assessment

Y Xie, X Su, Y Wen, C Zheng, M Li - Nano letters, 2022 - ACS Publications
Breast cancer subtypes have important implications of treatment responses and clinical
outcomes. Exosomes have been considered as promising biomarkers for liquid biopsies, but …

Advances of surface-enhanced Raman spectroscopy in exosomal biomarkers analysis

HS Tan, T Wang, HN Sun, A Liu, SS Li - TrAC Trends in Analytical …, 2023 - Elsevier
Cancer derived exosomal biomarkers (eg proteins, RNAs) could reflect important
information about the cancer microenvironment. For ultrasensitive analysis of exosomal …

[HTML][HTML] Molecular detection and analysis of exosomes using surface-enhanced Raman scattering gold nanorods and a miniaturized device

EA Kwizera, R O'Connor, V Vinduska, M Williams… - Theranostics, 2018 - ncbi.nlm.nih.gov
Exosomes are a potential source of cancer biomarkers. Probing tumor-derived exosomes
can offer a potential non-invasive way to diagnose cancer, assess cancer progression, and …

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer

J Carmicheal, C Hayashi, X Huang, L Liu, Y Lu… - … , Biology and Medicine, 2019 - Elsevier
Pancreatic cancer is a highly lethal malignancy. Lack of early diagnostic markers makes
timely detection of pancreatic cancer a highly challenging endeavor. Exosomes have …

A magnetic surface-enhanced Raman scattering platform for performing successive breast cancer exosome isolation and analysis

G Li, N Zhu, J Zhou, K Kang, X Zhou, B Ying… - Journal of Materials …, 2021 - pubs.rsc.org
The rapid development of exosome research provides new insights into the physiological
role of exosomes and their significant correlation with human health. Although the exosomes …

Dual-aptamer-assisted ratiometric SERS biosensor for ultrasensitive and precise identification of breast cancer exosomes

Q Zhang, R Ma, Y Zhang, J Zhao, Y Wang, Z Xu - ACS sensors, 2023 - ACS Publications
Due to the heterogeneity of breast cancer, its early accurate diagnosis remains a challenge.
Exosomes carry abundant genetic materials and proteins and are ideal biomarkers for early …

Correlation between cancerous exosomes and protein markers based on surface-enhanced Raman spectroscopy (SERS) and principal component analysis (PCA)

H Shin, H Jeong, J Park, S Hong, Y Choi - ACS sensors, 2018 - ACS Publications
Exosomes, which are nanovesicles secreted by cells, are promising biomarkers for cancer
diagnosis and prognosis, based on their specific surface protein compositions. Here, we …