[HTML][HTML] TNF-α and IL-1β modulate blood-brain barrier permeability and decrease amyloid-β peptide efflux in a human blood-brain barrier model

R Versele, E Sevin, F Gosselet, L Fenart… - International journal of …, 2022 - mdpi.com
The blood-brain barrier (BBB) is a selective barrier and a functional gatekeeper for the
central nervous system (CNS), essential for maintaining brain homeostasis. The BBB is …

[HTML][HTML] Blood-brain barrier dysfunction and the pathogenesis of Alzheimer's disease

Y Yamazaki, T Kanekiyo - International journal of molecular sciences, 2017 - mdpi.com
Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier

J Keaney, DM Walsh, T O'Malley, N Hudson… - Science …, 2015 - science.org
The blood-brain barrier (BBB) is essential for maintaining brain homeostasis and protecting
neural tissue from damaging blood-borne agents. The barrier is characterized by endothelial …

[HTML][HTML] The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease

YL Zhang, J Wang, ZN Zhang, Q Su… - Neural Regeneration …, 2022 - journals.lww.com
Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an
important influence on the onset and progression of chronic neurodegenerative processes …

[HTML][HTML] Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer's disease

A Jana, X Wang, JW Leasure, L Magana, L Wang… - Scientific Reports, 2022 - nature.com
Blood–brain barrier (BBB) dysfunction is emerging as a key pathogenic factor in the
progression of Alzheimer's disease (AD), where increased microvascular endothelial …

Role of blood-brain barrier in Alzheimer's disease

Z Cai, PF Qiao, CQ Wan, M Cai… - Journal of Alzheimer's …, 2018 - content.iospress.com
The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer's disease (AD).
BBB is a highly selective semipermeable structural and chemical barrier which ensures a …

Astrocytes contribute to Aβ‐induced blood–brain barrier damage through activation of endothelial MMP 9

SF Spampinato, S Merlo, Y Sano… - Journal of …, 2017 - Wiley Online Library
The blood–brain barrier (BBB) plays an important role in the maintenance of the brain
homeostasis, and its proper functions are warranted by the interplay between different …

Blood–brain barrier dysfunction as a cause and consequence of Alzheimer's disease

MA Erickson, WA Banks - Journal of Cerebral Blood Flow & …, 2013 - journals.sagepub.com
The blood–brain barrier (BBB) plays critical roles in the maintenance of central nervous
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease

AP Sagare, RD Bell… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

[HTML][HTML] The blood-brain barrier in Alzheimer's disease

E Zenaro, G Piacentino, G Constantin - Neurobiology of disease, 2017 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …