Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism
SA Sapouckey, G Deng, CD Sigmund… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS), originally described as a circulating hormone system,
is an enzymatic cascade in which the final vasoactive peptide angiotensin II (ANG) regulates …
is an enzymatic cascade in which the final vasoactive peptide angiotensin II (ANG) regulates …
Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide
SA Sapouckey, LL Morselli, G Deng… - American Journal …, 2020 - journals.physiology.org
Angiotensin II (ANG II) Agtr1a receptor (AT1A) is expressed in cells of the arcuate nucleus of
the hypothalamus that express the leptin receptor (Lepr) and agouti-related peptide (Agrp) …
the hypothalamus that express the leptin receptor (Lepr) and agouti-related peptide (Agrp) …
[HTML][HTML] Angiotensin AT1A receptors on leptin receptor–expressing cells control resting metabolism
KE Claflin, JA Sandgren, AM Lambertz… - The Journal of …, 2017 - Am Soc Clin Investig
Leptin contributes to the control of resting metabolic rate (RMR) and blood pressure (BP)
through its actions in the arcuate nucleus (ARC). The renin-angiotensin system (RAS) and …
through its actions in the arcuate nucleus (ARC). The renin-angiotensin system (RAS) and …
Control of energy expenditure by AgRP neurons of the arcuate nucleus: neurocircuitry, signaling pathways, and angiotensin
Abstract Purpose of Review Here, we review the current understanding of the functional
neuroanatomy of neurons expressing Agouti-related peptide (AgRP) and the angiotensin 1A …
neuroanatomy of neurons expressing Agouti-related peptide (AgRP) and the angiotensin 1A …
Recent advances in hypertension: intersection of metabolic and blood pressure regulatory circuits in the central nervous system
V Oliveira, AE Kwitek, CD Sigmund, LL Morselli… - …, 2021 - Am Heart Assoc
Obesity represents the single greatest ongoing roadblock to improving cardiovascular
health. Prolonged obesity is associated with fundamental changes in the integrative control …
health. Prolonged obesity is associated with fundamental changes in the integrative control …
[HTML][HTML] Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity
Resting metabolic rate (RMR) adaptation occurs during obesity and is hypothesized to
contribute to failed weight management. Angiotensin II (Ang-II) type 1 (AT 1A) receptors in …
contribute to failed weight management. Angiotensin II (Ang-II) type 1 (AT 1A) receptors in …
[HTML][HTML] Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus
R Yamamoto, H Akazawa, H Fujihara, Y Ozasa… - Journal of Biological …, 2011 - ASBMB
The activation of renin-angiotensin system contributes to the development of metabolic
syndrome and diabetes as well as hypertension. However, it remains undetermined how …
syndrome and diabetes as well as hypertension. However, it remains undetermined how …
The renin–angiotensin system in the arcuate nucleus controls resting metabolic rate
The RAS within the ARC is implicated specifically in RMR control, primarily through Agtr1a
localized to the SST3 subset of Agrp neurons. Ongoing research is focused on …
localized to the SST3 subset of Agrp neurons. Ongoing research is focused on …
[HTML][HTML] Suppression of resting metabolism by the angiotensin AT2 receptor
NK Littlejohn, HL Keen, BJ Weidemann, KE Claflin… - Cell reports, 2016 - cell.com
Activation of the brain renin-angiotensin system (RAS) stimulates energy expenditure
through increasing of the resting metabolic rate (RMR), and this effect requires simultaneous …
through increasing of the resting metabolic rate (RMR), and this effect requires simultaneous …
Melanocortin MC4R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain
V Oliveira, RA Riedl, KE Claflin… - Physiological …, 2022 - journals.physiology.org
The brain renin-angiotensin system (RAS) is implicated in control of blood pressure (BP),
fluid intake, and energy expenditure (EE). Angiotensin II (ANG II) within the arcuate nucleus …
fluid intake, and energy expenditure (EE). Angiotensin II (ANG II) within the arcuate nucleus …