Mitochondrial quality control is critical for cardiac homeostasis as these organelles are
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …

The function of mitochondria and lysosomes has classically been studied separately.
However, evidence has now emerged of intense crosstalk between these two organelles …

Mitochondrial respiration relies on electron transport, an essential yet dangerous process in
that it leads to the generation of reactive oxygen species (ROS). ROS can be neutralized …

Mitochondria are the powerhouses for the cell, consuming oxygen to generate sufficient
energy for the maintenance of normal cellular processes. However, a deleterious …

Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal.
The currently recognized mechanism for disposal of mitochondria is autophagy, where …

Energy stress, such as ischemia, induces mitochondrial damage and death in the heart.
Degradation of damaged mitochondria by mitophagy is essential for the maintenance of …

Sustained hypertension promotes structural, functional and metabolic remodeling of
cardiomyocyte mitochondria. As long-lived, postmitotic cells, cardiomyocytes turn over …

Mitochondria are critical metabolic and signaling hubs, and dysregulated mitochondrial
homeostasis is implicated in many diseases. Degradation of damaged mitochondria by …

Both mitochondria and lysosomes are essential for maintaining cellular homeostasis, and
dysfunction of both organelles has been observed in multiple diseases,,,. Mitochondria are …

Starvation-induced autophagosomes engulf cytosol and/or organelles and deliver them to
lysosomes for degradation, thereby resupplying depleted nutrients. Despite advances in …