A single bolus of docosahexaenoic acid promotes neuroplastic changes in the innervation of spinal cord interneurons and motor neurons and improves functional …

ZH Liu, PK Yip, L Adams, M Davies… - Journal of …, 2015 - Soc Neuroscience
Docosahexaenoic acid (DHA) is an ω-3 polyunsaturated fatty acid that is essential in brain
development and has structural and signaling roles. Acute DHA administration is …

A single dose of docosahexaenoic acid increases the functional recovery promoted by rehabilitation after cervical spinal cord injury in the rat

ZH Liu, PK Yip, JV Priestley… - Journal of …, 2017 - liebertpub.com
Task-specific rehabilitation has been shown to promote functional recovery after acute
spinal cord injury (SCI). Recently, the omega-3 polyunsaturated fatty acid, docosahexaenoic …

Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats

JD Figueroa, K Cordero, K Baldeosingh… - Journal of …, 2012 - liebertpub.com
Currently, few interventions have been shown to successfully limit the progression of
secondary damage events associated with the acute phase of spinal cord injury (SCI) …

Docosahexaenoic acid prevents white matter damage after spinal cord injury

RE Ward, W Huang, OE Curran, JV Priestley… - Journal of …, 2010 - liebertpub.com
We have previously shown that the omega-3 fatty acid docosahexaenoic acid (DHA)
significantly improves several histological and behavioral measures after spinal cord injury …

A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury

WL Huang, VR King, OE Curran, SC Dyall, RE Ward… - Brain, 2007 - academic.oup.com
Previous studies have shown that omega-3 polyunsaturated fatty acids such as α-linolenic
acid and docosahexaenoic acid (DHA) are neuroprotective in models of spinal cord injury …

Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid

SN Lim, W Huang, JCE Hall, AT Michael-Titus… - Experimental …, 2013 - Elsevier
In this study we have characterised the locomotor recovery, and temporal profile of cell loss,
in a novel thoracic compression spinal cord injury (SCI) in the mouse. We have also shown …

[HTML][HTML] Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies

I Paterniti, D Impellizzeri, R Di Paola, E Esposito… - Journal of …, 2014 - Springer
Background Two families of polyunsaturated fatty acid (PUFA), omega-3 (ω-3) and omega-6
(ω-6), are required for physiological functions. The long chain ω-3 PUFAs, eicosapentaenoic …

[HTML][HTML] Innovative mouse model mimicking human-like features of spinal cord injury: Efficacy of Docosahexaenoic acid on acute and chronic phases

S Marinelli, V Vacca, F De Angelis, L Pieroni, T Orsini… - Scientific reports, 2019 - nature.com
Traumatic spinal cord injury has dramatic consequences and a huge social impact. We
propose a new mouse model of spinal trauma that induces a complete paralysis of …

Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat

VR King, WL Huang, SC Dyall, OE Curran… - Journal of …, 2006 - Soc Neuroscience
Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory
treatment is currently available. Evidence suggests that polyunsaturated fatty acids (PUFAs) …

Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury

PK Yip, AL Bowes, JCE Hall… - Human molecular …, 2019 - academic.oup.com
Microglia are activated after spinal cord injury (SCI), but their phagocytic mechanisms and
link to neuroprotection remain incompletely characterized. Docosahexaenoic acid (DHA) …