Lipid-polysaccharide modified biohybrid nanoparticles (NPs) are eminent drug carriers for
brain targeting, owing to their ability to prolong the circulation time and penetrate the blood …

The objective of present research was to evaluate the potential of engineered solid lipid
nanoparticles (SLNs) as vectors to bypass the blood brain barrier. Anti-cancer agent …

Many nanoparticle matrixes have been demonstrated to be efficient in brain targeting, but
there are still certain limitations for them. To overcome the shortcomings of the existing …

There is a broad range of biological, chemical and physical hurdles for drugs to reach the
brain. Nanoparticulate drug delivery systems hold tremendous potential for diagnosis and …

The object of the present study was to investigate the glioma targeting propensity of folic
acid (F) decorated polymer–lipid hybrid nanoparticles (PLNs) encapsulating cyclo-[Arg-Gly …

The blood–brain barrier is considered the leading physiological obstacle hindering the
transport of neurotherapeutics to brain cells. The application of nanotechnology coupled …

Multiple sclerosis (MS) is a chronic central nervous system (CNS) inflammation. Efficient
drug delivery to brain is however hampered by blood–brain barrier (BBB). In order to have …

The aim of any drug delivery system is not only to deliver a drug to specific site of action but
also to maintain its therapeutic concentration at the targeted site. Most of the drugs used in …

Drug distribution to the brain is one of the most difficult challenges in the treatment of the
central nervous system (CNS) diseases due to the presence of the blood-brain barrier …

This research aimed to design, optimize, and evaluate berberine-laden nanostructured lipid
carriers overlaid with chitosan (BER-CTS-NLCs) for efficient brain delivery via the intranasal …