Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …

Microbial natural products have provided an important source of therapeutic leads and
motivated research and innovation in diverse scientific disciplines. In recent years, it has …

Secondary metabolites from microorganisms have a broad spectrum of applications,
particularly in therapeutics. The growing number of sequenced microbial genomes has …

Highlights•Silent BGC expression can be promoted by creative co-culture and elicitor
exposure.•Novel regulators are enabling new approaches to stimulating BGC …

Bacteria contain an immense untapped trove of novel secondary metabolites in the form of
'silent'biosynthetic gene clusters (BGCs). These can be identified bioinformatically but are …

Natural products (NPs) produced by bacteria and fungi are often used as therapeutic agents
due to their complex structures and wide range of bioactivities. Enzymes that build NPs are …

Anaerobic bacteria represent an overlooked rich source of biological and chemical diversity.
Due to the challenge of cultivation and genetic intractability, assessing the capability of their …

Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional
interest owing to their unique biomedical ramifications. The traditional discovery of new …

Abstract The World Health Organization (WHO) describes antibiotic resistance as “one of the
biggest threats to global health, food security, and development today”, as the number of …

Microorganisms have a long track record as important sources of novel bioactive natural
products, particularly in the field of drug discovery. While microbes have been shown to …