Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in
vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms …

AIMS: Melatonin is a hormone synthesized principally in the pineal gland that has been
classically associated with endocrine actions. However, several lines of evidence suggest …

Melatonin is an endogenous neurohormone that is produced in most living organisms,
including unicellular and multicellular organisms, plants, vertebrates, and nonvertebrate …

Melatonin (N-acetyl-5-methoxytryptamine), secreted by the pineal gland is known to perform
multiple functions including, antioxidant, anti-hypertensive, anti-cancerous …

Melatonin is a neurohormone secreted by epiphysis and extrapineal structures. It performs
several functions including chronobiotic, antioxidant, oncostatic, immune modulating …

Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin
has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative …

Pain and anxiety are the most common neurological responses to many harmful or noxious
stimuli and their management clinically is often challenging. Many of the frequently used …

The perception of pain is altered by inflammatory processes. Anti‐inflammatory drugs block
this by raising the pain threshold and by reducing the inflammatory process. Melatonin is …

Melatonin, the hormone of darkness has many physiological functions in the body and also
exerts a number of pharmacological effects. Most of these actions of melatonin are mediated …

The intensity of pain sensation exhibits marked day and night variations. Since the intensity
of pain perception is low during dark hours of the night when melatonin levels are high, this …