Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms
normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors …

Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

The balance of histone acetylation and deacetylation is an epigenetic layer with a critical
role in the regulation of gene expression. Histone acetylation induced by histone acetyl …

In the current era of genomic medicine, diseases are identified as manifestations of
anomalous patterns of gene expression. Cancer is the principal example among such …

Genetic abnormalities have been conventionally considered as hallmarks of cancer.
However, studies over the past decades have demonstrated that epigenetic regulation also …

Over decades of studies, accumulating evidence has suggested that epigenetic
dysregulation is a hallmark of tumours. Post-translational modifications of histones are …

Since the identification and cloning of human histone deacetylases (HDACs) and the rapid
approval of vorinostat (Zolinza®) for the treatment of cutaneous T-cell lymphoma, the field of …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Enzymes which affect histone acetylation status have been shown to play an important role
in determining transcriptional activity in chromatin through conformational modification of its …