Background Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing
compounds with good safety profiles which have been investigated for their benefits and …

Intraperitoneal chemotherapy together with cytoreductive surgery is the standard of care for
a number of peritoneal surface malignancies. However, this approach fails to maintain the …

Background Bromelain is a pineapple stem extract with a variety of therapeutic benefits
arising from interaction with a number of different biological processes. Several preclinical …

Advanced colorectal cancer (CRC) survival rates are still low despite advances in cytotoxic
and targeted therapies. The development of new effective or alternative therapies is …

Current systemic dosages of chemotherapeutic drugs such as gemcitabine, 5-FU, cisplatin,
doxorubicin are administered every 7 days over 4 cycles due to systemic toxicity. An …

The pineapple, botanically named Ananas comosus, has been used for centuries as a folk
medicine by the indigenous inhabitants of Central and South America. The medicinal …

Background The chemopreventive effects of dietary phytochemicals on malignant tumors
have been studied extensively because of a relative lack of toxicity. To achieve desirable …

The combinations of Bromelain and Acetylcysteine (BromAc®) with cytotoxics such as
Gemcitabine, 5-Fluorouracil or Oxaliplatin have shown a dramatic reduction in IC50 values …

The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …

Cholangiocarcinoma (CC) worldwide is the most common biliary malignancy with poor
prognostic value and new systemic treatments are desirable. Plant extracts like bromelain …