Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …
[PDF][PDF] Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart
failure, and premature death. The pathogenesis of AF remains poorly understood, which …
failure, and premature death. The pathogenesis of AF remains poorly understood, which …
Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond
Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke
and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic …
and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic …
Multi-ethnic genome-wide association study for atrial fibrillation
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …
heritability. We conducted the largest meta-analysis of genome-wide association studies …
Genetic control of left atrial gene expression yields insights into the genetic susceptibility for atrial fibrillation
J Hsu, S Gore-Panter, G Tchou, L Castel… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: Genome-wide association studies have identified 23 loci for atrial fibrillation
(AF), but the mechanisms responsible for these associations, as well as the causal genes …
(AF), but the mechanisms responsible for these associations, as well as the causal genes …
Identification of atrial fibrillation associated genes and functional non-coding variants
AF van Ouwerkerk, FM Bosada… - Nature …, 2019 - nature.com
Disease-associated genetic variants that lie in non-coding regions found by genome-wide
association studies are thought to alter the functionality of transcription regulatory elements …
association studies are thought to alter the functionality of transcription regulatory elements …
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
PT Ellinor, KL Lunetta, CM Albert, NL Glazer… - Nature …, 2012 - nature.com
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart
failure and death. We conducted a genome-wide association study (GWAS) in individuals of …
failure and death. We conducted a genome-wide association study (GWAS) in individuals of …
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation
Background—Atrial fibrillation (AF) affects> 30 million individuals worldwide and is
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable …
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable …
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population
Atrial fibrillation is the most common cardiac arrhythmia and leads to stroke. To investigate
genetic loci associated with atrial fibrillation in the Japanese population, we performed a …
genetic loci associated with atrial fibrillation in the Japanese population, we performed a …
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