Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

JB Nielsen, RB Thorolfsdottir, LG Fritsche, W Zhou… - Nature …, 2018 - nature.com
To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

IE Christophersen, M Rienstra, C Roselli, X Yin… - Nature …, 2017 - nature.com
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …

[PDF][PDF] Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development

JB Nielsen, LG Fritsche, W Zhou, TM Teslovich… - The American Journal of …, 2018 - cell.com
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart
failure, and premature death. The pathogenesis of AF remains poorly understood, which …

Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond

C Roselli, M Rienstra, PT Ellinor - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke
and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic …

Multi-ethnic genome-wide association study for atrial fibrillation

C Roselli, MD Chaffin, LC Weng, S Aeschbacher… - Nature …, 2018 - nature.com
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …

Genetic control of left atrial gene expression yields insights into the genetic susceptibility for atrial fibrillation

J Hsu, S Gore-Panter, G Tchou, L Castel… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: Genome-wide association studies have identified 23 loci for atrial fibrillation
(AF), but the mechanisms responsible for these associations, as well as the causal genes …

Identification of atrial fibrillation associated genes and functional non-coding variants

AF van Ouwerkerk, FM Bosada… - Nature …, 2019 - nature.com
Disease-associated genetic variants that lie in non-coding regions found by genome-wide
association studies are thought to alter the functionality of transcription regulatory elements …

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

PT Ellinor, KL Lunetta, CM Albert, NL Glazer… - Nature …, 2012 - nature.com
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart
failure and death. We conducted a genome-wide association study (GWAS) in individuals of …

Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation

MF Sinner, NR Tucker, KL Lunetta, K Ozaki, JG Smith… - Circulation, 2014 - Am Heart Assoc
Background—Atrial fibrillation (AF) affects> 30 million individuals worldwide and is
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable …

Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

SK Low, A Takahashi, Y Ebana, K Ozaki… - Nature …, 2017 - nature.com
Atrial fibrillation is the most common cardiac arrhythmia and leads to stroke. To investigate
genetic loci associated with atrial fibrillation in the Japanese population, we performed a …