Molecular Mechanisms of Neuroprotection by Ketone Bodies and Ketogenic Diet in Cerebral Ischemia and Neurodegenerative Diseases
J Jang, SR Kim, JE Lee, S Lee, HJ Son… - International journal of …, 2023 - mdpi.com
Ketone bodies (KBs), such as acetoacetate and β-hydroxybutyrate, serve as crucial
alternative energy sources during glucose deficiency. KBs, generated through ketogenesis …
alternative energy sources during glucose deficiency. KBs, generated through ketogenesis …
Ketone bodies in neurological diseases: focus on neuroprotection and underlying mechanisms
H Yang, W Shan, F Zhu, J Wu, Q Wang - Frontiers in neurology, 2019 - frontiersin.org
There is growing evidence that ketone bodies, which are derived from fatty acid oxidation
and usually produced in fasting state or on high-fat diets have broad neuroprotective effects …
and usually produced in fasting state or on high-fat diets have broad neuroprotective effects …
Ketogenic diet and ketone bodies against ischemic injury: targets, mechanisms, and therapeutic potential
CI Makievskaya, VA Popkov, NV Andrianova… - International journal of …, 2023 - mdpi.com
The ketogenic diet (KD) has been used as a treatment for epilepsy since the 1920s, and its
role in the prevention of many other diseases is now being considered. In recent years, there …
role in the prevention of many other diseases is now being considered. In recent years, there …
Ketogenic diet: a promising neuroprotective composition for managing Alzheimer's diseases and its pathological mechanisms
B Sridharan, MJ Lee - Current Molecular Medicine, 2022 - ingentaconnect.com
Ketogenic diet and ketone bodies gained significant attention in recent years due to their
ability to influence the specific energy metabolism and restoration of mitochondrial …
ability to influence the specific energy metabolism and restoration of mitochondrial …
Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia. AD is a progressive
neurodegenerative disorder characterized by cognitive dysfunction, including learning and …
neurodegenerative disorder characterized by cognitive dysfunction, including learning and …
[HTML][HTML] Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases
Z Jiang, X Yin, M Wang, T Chen, Y Wang, Z Gao… - Aging and …, 2022 - ncbi.nlm.nih.gov
The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As a diet
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …
Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases
NJ Jensen, HZ Wodschow, M Nilsson… - International journal of …, 2020 - mdpi.com
Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
[HTML][HTML] 𝜷-hydroxybutyric acid attenuates oxidative stress and improves markers of mitochondrial function in the HT-22 hippocampal cell line
M Majrashi, M Altukri, S Ramesh… - Journal of Integrative …, 2021 - imrpress.com
Ketone bodies have been the topic of research for their possible therapeutic neurotropic
effects in various neurological diseases such as Parkinson's disease, dementia, and …
effects in various neurological diseases such as Parkinson's disease, dementia, and …
Neuroprotection by the ketogenic diet: evidence and controversies
SM Gough, A Casella, KJ Ortega, AS Hackam - Frontiers in Nutrition, 2021 - frontiersin.org
The ketogenic diet (KD) is a high-fat low-carbohydrate diet that has been used for decades
as a non-pharmacologic approach to treat metabolic disorders and refractory pediatric …
as a non-pharmacologic approach to treat metabolic disorders and refractory pediatric …
Therapeutic strategies for ketosis induction and their potential efficacy for the treatment of acute brain injury and neurodegenerative diseases
L Camberos-Luna, L Massieu - Neurochemistry international, 2020 - Elsevier
The therapeutic use of ketone bodies (KB) against acute brain injury and neurodegenerative
disorders has lately been suggested by many studies. Several mechanisms responsible for …
disorders has lately been suggested by many studies. Several mechanisms responsible for …
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