Placentae from pregnancies with foetal growth restriction (FGR) exhibit poor oxygen and
nutrient exchange, in part due to impaired placental vascular development. Placental …

The extensively branched vascular network within the placenta is vital for materno-fetal
exchange, and inadequate development of this network is implicated in the pregnancy …

Growth-restricted placentae have a reduced vascular network, impairing exchange of
nutrients and oxygen. However, little is known about the differentiation events and cell types …

Human placental mesenchymal stromal cells (pMSCs) have never been investigated in
intrauterine growth restriction (IUGR). We characterized cells isolated from placental …

We studied the smooth muscle cell differentiation capability of human placental multipotent
mesenchymal stromal cells (hPMSCs) and identified how endothelial cells recruit hPMSCs …

Single-cell technologies (RNA-sequencing, flow cytometry) are critical tools to reveal how
cell heterogeneity impacts developmental pathways. The placenta is a fetal exchange …

Introduction Derivation of pure fetal placental mesenchymal stem/stromal cells (pMSCs) is
key to understand their role in placental development. However, isolated pMSCs are often …

The microenvironment of placental mesenchymal stem cells (PMSCs) is dynamic throughout
gestation and determines changes in cell fate. In vivo, PMSCs initially develop in low …

The successful transformation of uterine spiral arteries by invasion trophoblasts is critical for
the formation of the human hemochorial placenta. Placental trophoblast migration and …

Introduction Little is known about the interaction between human placental multipotent
mesenchymal stromal cell (hPMSC) and trophoblast. We hypothesize that hPMSCs produce …